GASTROINTESTINAL LYMPHATIC TISSUE SAMPLING TO DETERMINE ACTIVE HIV1 REPLICATE

有令人信服的理论理由来研究病毒和免疫 HIV感染者肠道相关淋巴组织（GALT）的反应 接受过抗逆转录病毒药物治疗的人。 的 GALT含有体内约50%的淋巴物质， 在许多患者中作为初始HIV接种的部位， GALT中绝大多数淋巴细胞表达记忆表型， 标记（例如，CD45RO）和慢性激活，这增强了艾滋病毒 感染这些细胞。 我们将评估感染了 艾滋病毒以及被困在这个身体隔室的FDC网络中的艾滋病毒， 面对强效抗逆转录病毒药物组合。 我们还将 评估GALT中CD4+淋巴细胞的再增殖率， 发生在它们在外周血中重新聚集之前。

There are compelling theoretical reasons to study the viral and immune response in the gut-associated lymphoid tissue (GALT) in HIV-infected individuals who have been treated with antiretroviral medication. The GALT contains approximately 50% of the lymphoid mass in the body, it serves as the site of initial HIV inoculation in many patients, and the vast majority of the lymphocytes in the GALT express memory phenotypic markers (e.g., CD45RO) and are chronically activated, which enhances HIV infection of these cells. We will evaluate the decay cells infected with HIV as well as trapped HIV in the FDC-network in this body compartment in the face of potent combination antiretroviral medication. We will also evaluate the repopulation rate of CD4+ lymphocytes in the GALT that may occur prior to their repopulation in the peripheral blood.