PHYSIOLOGIC EFFECT OF OPIOID PEPTIDES AND THEIR CONGENERS--DYNORPHIN A PEPTIDES

阿片肽及其同源物强啡肽A的生理作用

• 批准号: 6246929
• 负责人: MARY J KREEK
• 金额: $ 5.86万
• 依托单位: ROCKEFELLER UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-27 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6246929
• 关键词: clinical research; drug interactions; dynorphins; human subject; hypothalamic pituitary axis; pituitary gonadal axis

Since dynorphin A1-17 has been shown by previous studies to be presumably the major endogenous kappa ligand and its effects would be shared by both the shorter dynorphin A1-13 as well as the shorter and stabilized dynorphin A1-10 amide, we are conducting studies of the effects of these dynorphin A peptides in normal volunteer subjects both to determine the effects on hormones of the hypothalamic-pituitary-adrenal axis, as well as hormones of the hypothalamic-pituitary-gonadal axis, prolactin, and other neuropeptides and neuro-transmitter systems and their effects on immune function.

因为之前的研究表明强啡肽A1-17可能是 主要的内源性kappa配体及其作用将由两者共享 较短的强啡肽A1-13以及较短和稳定的 强啡肽A1-10酰胺，我们正在进行这些影响的研究 强啡肽A在正常志愿者体内的检测 对下丘脑-垂体-肾上腺轴激素的影响 下丘脑-垂体-性腺轴的激素、催乳素和其他 神经肽和神经递质系统及其在免疫中的作用 功能。