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PHYSIOLOGIC EFFECT OF OPIOID PEPTIDES AND THEIR CONGENERS--DYNORPHIN A PEPTIDES

PHYSIOLOGIC EFFECT OF OPIOID PEPTIDES AND THEIR CONGENERS--DYNORPHIN A PEPTIDES
阿片肽及其同源物强啡肽A的生理作用
批准号:
6246929
负责人:
MARY J KREEK
金额:
$5.86万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1997
资助国家:
美国
项目状态:
已结题
起止时间:
1997-01-27 至 1997-11-30

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中文摘要
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英文摘要
Since dynorphin A1-17 has been shown by previous studies to be presumably the major endogenous kappa ligand and its effects would be shared by both the shorter dynorphin A1-13 as well as the shorter and stabilized dynorphin A1-10 amide, we are conducting studies of the effects of these dynorphin A peptides in normal volunteer subjects both to determine the effects on hormones of the hypothalamic-pituitary-adrenal axis, as well as hormones of the hypothalamic-pituitary-gonadal axis, prolactin, and other neuropeptides and neuro-transmitter systems and their effects on immune function.
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