ENERGY METABOLISM IN THE POST OBESE STATE

肥胖后状态的能量代谢

• 批准号: 6247049
• 负责人: ERIC T. POEHLMAN
• 金额: $ 2.44万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-23 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6247049
• 关键词: beta adrenergic receptor; bioenergetics; clinical research; gene mutation; human subject; lipolysis; noninsulin dependent diabetes mellitus; obesity

A novel mutation in the B3-adrenergic receptor gene was recently detected in a number of populations. This mutation predicts a minor amino acid change in the first intracellular loop of this seven membrane-spanning receptor. The B3 adrenergic receptor is thought to play an important role in the regulation of energy expenditure & lipolysis . Subjects who harbor the mutation tend to have a lower resting metabolic rate, higher body mass index & earlier onset of typeII diabetes.

B3-肾上腺素受体基因中的一种新型突变是最近的 在许多人群中检测到。这个突变预测了一个小小的 这七个的第一个细胞内环中的氨基酸变化 跨膜受体。 B3肾上腺素能受体被认为是 在能源消耗的调节中发挥重要作用 脂解。藏有突变的受试者往往较低 静息代谢率，更高的体重指数和类型的早期发作 糖尿病。