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REPORTER GENE MUTATIONS IN MYELOID STEM CELLS

REPORTER GENE MUTATIONS IN MYELOID STEM CELLS
骨髓干细胞中的报告基因突变
批准号：
6247052
负责人：
BARBARA W GRANT
金额：
$2.44万
依托单位：
UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-01-23 至 1997-11-30
来源：
https://reporter.nih.gov/project-details/6247052
关键词：
bone marrow disorder clinical research gene mutation human middle age (35-64) human old age (65+) human subject human tissue hypoxanthine phosphoribosyltransferase myeloid stem cell prognosis reporter genes

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英文摘要
Work to date has established that lymphocytes bear the same mutational burdens as myeloid stem cells. Age, chemotherapy and myelodysplasia are associated with above-average incidence of mutation at the reporter gene hprt (hypoxanthine ribosyltransferase). We plan to strengthen the data thus far compiled by increasing the normal cohort of 60 to 70 year olds, and by studying more patients with myelodysplasia. Approximately 10 more marrow and blood samples will be obtained on the CRC by October 1997.
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REPORTER GENE MUTATIONS IN MYELOID STEM CELLS
HUMAN MEGAKARYOPOIESIS
HUMAN MEGAKARYOPOIESIS
REPORTER GENE MUTATIONS IN MYELOID STEM CELLS
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