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REPORTER GENE MUTATIONS IN MYELOID STEM CELLS

REPORTER GENE MUTATIONS IN MYELOID STEM CELLS
骨髓干细胞中的报告基因突变
批准号：
6115952
负责人：
BARBARA W GRANT
金额：
$3.29万
依托单位：
UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6115952
关键词：
bone marrow disorder clinical research gene mutation human middle age (35-64) human old age (65+) human subject human tissue hypoxanthine phosphoribosyltransferase myeloid stem cell prognosis reporter genes

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英文摘要
Little is understood about which pts are at risk for therapy-associated acute myeloid leukemia. The reporter gene hprt has established sensitivity & specificity as a biomarker in lymphocytes for detecting in vivo somatic mutation due to chemotherapy. We recently developed methods to measure in vivo hprt somatic mutation in myeloid stem cells & to analyze the molecular nature of the mutations. We hypothesize that hprt in myeloid cells will reflect the specific mutational pressure of cytotoxic therapies that lead to tAML.
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HUMAN MEGAKARYOPOIESIS
REPORTER GENE MUTATIONS IN MYELOID STEM CELLS
REPORTER GENE MUTATIONS IN MYELOID STEM CELLS
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