课题基金 / 基金详情

INHIBITION OF HIV 1 USING A MUTANT TRNA PRIMER

INHIBITION OF HIV 1 USING A MUTANT TRNA PRIMER
使用突变 TRNA 引物抑制 HIV 1
批准号：
2431632
负责人：
Joseph David Rosenblatt
金额：
$17.61万
依托单位：
UNIVERSITY OF ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-07-01 至 2001-06-30
来源：
https://reporter.nih.gov/project-details/2431632
关键词：
HIV infections RNA directed DNA polymerase Retroviridae antiAIDS agent antiviral agents gene expression genetic manipulation genetic regulation genetic transcription human immunodeficiency virus 1 mutant tissue /cell culture transfer RNA virus infection mechanism virus replication

项目摘要

项目成果

Joseph David Rosenblatt的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
DESCRIPTION: (adapted from the investigator's abstract) This is a proposal for funds to investigate the inhibition of retroviral replication through interference with the normal process of priming. The investigator suggests that this approach is a novel anti-retroviral approach and also provides a powerful tool for dissecting molecular aspects of priming. The proposal focuses on the molecular and virological mechanisms underlying inhibition of HIV-1 replication by mutant tRNAs. The investigator plans to pursue three specific objectives: First, he will elucidate the mechanism(s) by which mutant tRNA expression leads to marked suppression of HIV-1 replication and use this knowledge to design second generation tRNA mutants with enhanced ability to inhibit HIV-1 replication; second, he will analyze virus recovered from mutant tRNA-transduced cells for potential escape mechanisms; and third, he will examine the effect of mutant tRNA-based inhibition in combination with anti-viral drugs which target reverse transcription.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Host Defense Regulation by HTLV-1
Augmentation of Anti-Tumor Activity in the Absence of B Cells
HSV Amplicon Activation of Innate and Adaptive Immunity
HSV Amplicon Activation of Innate and Adaptive Immunity
海外基金