GEOGRAPHIC AND MOLECULAR CLUSTERING OF TUBERCULOSIS

结核病的地理和分子聚类

• 批准号: 2005168
• 负责人: Gregory E Glass
• 金额: $ 8.43万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-01 至 2000-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2005168
• 关键词: Mycobacterium tuberculosis; behavioral /social science research tag; clinical research; disease /disorder proneness /risk; genetic strain; human data; outcomes research; respiratory disorder chemotherapy; respiratory disorder epidemiology; therapy compliance; tuberculosis

DESCRIPTION: Urban TB is a persistent problem that has caused substantial morbidity and emerged as a renewed public health threat during the past several years. Studies of its transmission have been substantially enhanced by the advent of molecular methods for strain typing. These have permitted the realization, for instance, that a higher proportion of cases of TB represent recent acquisition of infection, rather than reactivation of disease. The application proposes to combine these molecular methods with geographic information systems (GIS) technology and methods to further elucidate the epidemiology of TB, and also to assess the impact of DOT on the distribution of cases. The combination of molecular TB strain genotyping and GIS approaches will be used to track microepidemics and to test the hypothesis that genetically related cases of TB occur within a more restricted geographic area than sporadic cases and are more likely to be the result of incident cases than of reactivation of latent infections, which is more likely in low prevalence areas. The outcome goal is try to understand factors that promulgate high rates of spread in areas with persistent clonal TB microepidemics and to try to develop intervention strategies.

描述：城市结核病是一个持续存在的问题， 发病率，并在过去成为一个新的公共卫生威胁 几年 关于其传播的研究已大大加强 病毒分型的分子方法的出现。 这使得 例如，人们认识到， 代表最近获得感染，而不是重新激活 疾病 本申请提出将这些分子方法与以下方法联合收割机组合： 地理信息系统（GIS）技术和方法， 阐明结核病的流行病学，并评估DOT对 案件的分布。 分子结核菌株 基因分型和GIS方法将用于跟踪微流行病， 测试这一假设，即遗传相关的结核病病例发生在一个更大的范围内， 有限的地理区域比散发病例，更有可能是 而不是潜伏感染的重新激活， 在低发病率地区更有可能。 结果目标是试图理解 在持续克隆的地区传播率高的因素 结核病微流行病，并试图制定干预策略。