权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Ecology of Andes & Choclo Viruses

安第斯山脉生态

基本信息

批准号：
7619541
负责人：
Gregory E Glass
金额：
$ 32.46万
依托单位：
UNIVERSITY OF NEW MEXICO
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/7619541
关键词：
Age Agreement Andes Virus Animal Model Animals Area Behavior Behavioral Biological Models Biology Blood Breathing Cardiopulmonary Categories Characteristics Chile Communities Comparative Study Complex Condition Contracts Country Data Developed Countries Developing Countries Diagnostic Procedure Disease Ecology Environment Environmental Risk Factor Excretory function Facility Construction Funding Category Future Gender Geographic Locations Goals Graph Growth Habitats Hantavirus Hantavirus Infections Human Human Activities Imagery In Situ Incidence Individual Infection Investigation Knowledge Laboratories Life Link Localized Location Longitudinal Studies Maps Measures Methods Modeling Molecular Molecular Epidemiology Monitor Movement Numbers Observational Study Organism Outcome Output Panama Pattern Population Population Density Population Dynamics Population Growth Population Study Prevalence Probability Process Purpose Radio Range Rate Reproduction Reproductive History Resolution Resources Risk Rodent Rodent Model Rural Sampling Seasons Series Serological Seroprevalences Site Source Spatial Distribution Stress Structure Surveys Syndrome Telemetry Testing Theoretical model Thinking Time Tissues United States Urine Validation Viral Viral Load result Virus Virus Diseases Work Zoonoses agricultural activity base comparative density design disorder risk environmental intervention field study human disease human ecology improved infected vector rodent insight member mortality pathogen preference remote sensing residence response size spatial relationship spatial temporal variation theories time use transmission process vegetation habitat

项目摘要

Hantavirus cardiopulmonary syndrome resulting from any of a number of hantaviruses in the western hemisphere is thought to be contracted through inhalation of infected rodent excreta. In southern and central Chile, the Andes virus infects the sigmodontine rodent Oligoryzomys longicaudatus, and causes a rare but severe human infection with high mortality. In western Panama, the Choclo virus infects the rodent Oligoryzomys fulvescens and causes a common but usually mild or inapparent human infection with a low mortality rate. In both regions the risk of transmission appears to be influenced by many factors increasing the opportunity for close contact between infected rodents and susceptible humans. We will focus our investigations on three of these factors, with the goal of gaining insights critical for the design of future environmental interventions to decrease hantavirus transmission. First, recent investigations in Chile and Panama have associated risk of infection with selected vegetation habitats favored by the infected vector rodents. In Chile exposure risk can be predicted by remote sensing with satellite imagery analysis over 2/3 of the country. In Panama a micro scale analysis has suggested complex relationships between peridomestic infected rodents and agricultural activities. We propose to focus on spatial relationships between rodents and habitats over time, using mark-recapture trapping and radiotelemetry to mark rodent movements, particularly in peridomestic environments. Second we will create a dynamic model that extends our current static analysis of risk. The new model will apply graph theory to field collected data of rodent habitat preferences and movements within the landscape to predict the likely movement of infected rodents. We will test the model using data from sites different from those used to create the model. The temporal precision of the model will be improved by quantitating viral load in rodent blood, tissue and urine in the winter (low transmission) and spring (high transmission) seasons. Finally, serial serosurveys of at-risk human populations in Panama will quantify the impact on human infection associated with spatial-temporal variations in rodent density and movement.

汉坦病毒心肺综合征由西部的汉坦病毒引起的