ROCHESTER EPIDEMIOLOGY PROJECT

描述：(改编自申请者摘要)The Rochester 流行病学项目(REP)是一个病历链接系统， 包括向罗切斯特和奥姆斯特德的居民提供的护理 明尼苏达州的县。通过允许访问详细的住院患者和 社区卫生服务提供者的门诊病历， 这一独特的数据资源能够提供准确的发病率和 几乎所有疾病或综合征的50年或更长时间的趋势数据 支持以人群为基础的病因和结果研究。它让人 有可能有效地实施关于 心脏病、中风、痴呆症、癌症、糖尿病、 消化系统疾病、骨质疏松症、关节炎和其他有 自1966年该系统成立以来，最终出版了813份出版物 包括过去四年中的353个(已发表261个，接受或提交92个) 好几年了。尽管梅奥诊所为支持 该数据库通过对其自身记录中引用的医疗事件进行索引 在这个项目没有成本的情况下，需要持续的外部支持来 从社区中的非Mayo提供者那里收集诊断数据 将来自所有护理来源的信息整合到一个真正的 基于人口的数据存储库。具体地说，继续提供资金是 需要：(1)增强和维护枚举性和唯一性 奥姆斯特县居民身份识别是必要的 该数据系统的核心；(2)继续收集医疗事件数据 (例如，诊断、程序)来自非梅奥医疗保健提供者 1995至1999年，以确保完全查明案件和 跟进；(3)完成并维护代表主文件(关系文件 该数据库将提供医疗事件与 该县的被统计人口)，并开始整合 关于医疗事件的电子信息量不断增加 护理和住院、临床和病理诊断、外科手术 和诊断程序、化验值、处方药和数据 从特定的研究文件或注册到该数据库；以及(4) 通过进一步自动化改善对流行病学研究的后勤支持 研究程序和开发其他分析工具。这些 活动对于继续支持这一大型机构是不可或缺的 在这一人群中正在进行的流行病学研究的 来自梅奥诊所和全国各地其他中心的调查人员， 包括由美国国立卫生研究院资助的20项独立研究 在之前的授权期内。这些研究有助于增加 了解多种具有社会意义的疾病过程 全国范围内。尽管基础数据系统运行良好，但这些目标 将允许调查人员扩展这项研究的能力 基础设施和进一步验证罗切斯特流行病学项目 数据库和调查方法。

DESCRIPTION: (Adapted from Applicant's Abstract) The Rochester Epidemiology Project (REP) is the medical records linkage system that encompasses the care delivered to residents of Rochester and Olmsted County, Minnesota. By affording access to the detailed inpatient and outpatient medical records of health care providers in the community, this unique data resource is able to provide accurate incidence and trend data over 50 years or more for nearly any disease or syndrome and to support population-based studies of etiology and outcome. It makes possible the efficient implementation of important studies on the epidemiology of heart disease, stroke, dementia, cancer, diabetes, digestive diseases, osteoporosis, arthritis and other disorders that have culminated in 813 publications since the system was organized in 1966 including 353 (261 published; 92 accepted or submitted) in the past four years. Although Mayo Clinic contributes substantially to the support of this database by indexing the medical events cited in its own records at no cost to this project, ongoing extramural support is needed to collect diagnostic data from the non-Mayo providers in the community and to integrate the information from all sources of care into a true population-based data repository. Specifically, continued funding is needed to: (1) enhance and maintain the enumeration and unique identification of Olmsted County residents which serves as the essential core of this data system; (2) continue collecting medical event data (e.g., diagnoses, procedures) from the non-Mayo providers of health care for 1995 through 1999 in order to ensure complete case ascertainment and follow-up; (3) complete and maintain the REP Master file (the relational database which will provide electronic linkage of medical events with the enumerated population of the county) and to begin integrating the increasing volume of electronic information about episodes of medical care and hospitalization, clinical and pathological diagnoses, surgical and diagnostic procedures, laboratory values, prescription drugs and data from specific study files or registries into this database; and (4) improve logistic support for epidemiologic studies by further automating study procedures and by developing additional analytic tools. These activities are indispensable to the continued support of the large body of epidemiologic research that is being conducted in this population by investigators from Mayo Clinic and other centers throughout the country, including 20 separate studies funded by the National Institutes of Health during the previous grant period. These studies have served to increase knowledge of a multitude of disease processes of social significance nationally. Although the basic data system has worked well, these aims will allow the investigators to extend the capabilities of this research infrastructure and to further validate the Rochester Epidemiology Project databases and investigative approaches.