RISK FACTORS FOR FRACTURES AMONG THE ELDERLY
RISK FACTORS FOR FRACTURES AMONG THE ELDERLY
批准号:
7650702
负责人:
L. JOSEPH MELTON
金额:
$38.52万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-07-01 至 2014-06-30
关键词:
AccountingAdultAdverse effectsAgeAgingAlgorithmsArtsCaringCase-Control StudiesCharacteristicsChildChildhoodClinicalCohort StudiesCommunitiesComplementCountyDataDatabasesDiagnosisDistalEconomic InflationEconomicsElderlyEpidemiologic MethodsEpidemiologyEstrogensExpenditureFemaleForearmForearm FractureFoundationsFractureFrequenciesFunctional disorderFundingFutureGenderGlucocorticoidsGoalsGonadal Steroid HormonesHealthcareHip FracturesHip region structureHistorical Cohort StudiesIncidenceIndividualInflammatoryInpatientsInstructionInterventionInvestigationKnowledgeLifeLightLiteratureMedicalMedical Record LinkageMenopauseMetabolic Bone DiseasesMethodologyOsteoporosisOutcomeOutpatientsPatientsPhysiologyPoliciesPolicy AnalysisPopulationPredisposing FactorPreventionProgram Research Project GrantsProphylactic treatmentPublic HealthRecording of previous eventsResearch DesignResourcesRheumatoid ArthritisRiskRisk AssessmentRisk FactorsSiteStructureSystemTestingTimeTreatment EffectivenessUpdateWomanWorld Health OrganizationYouthadvanced diseaseage groupage relatedaggressive therapyaging populationbonebone lossbone massbone metabolismcohortcostcost effectivenesshigh riskhumerusmalemennew technologynursing home length of stayosteoporosis with pathological fractureoutcome forecastpopulation basedresponsesexskeletalspine bone structuretrendvolunteer
中文摘要
点击翻译按钮获取中文摘要
英文摘要
Project 2, "Risk Factors for Fracture Among the Elderly," complements the pathophysiology studies in this
Program Project Grant by providing a population perspective on risk factors for, and consequences of,
osteoporotic fractures. We propose to continue our focus on better identifying risk factors for long-term
fracture outcomes by conducting large historical cohort studies of Olmsted County, MN residents with
specific conditions that exacerbate bone loss from estrogen deficiency and aging ("secondary"
osteoporosis). We also will provide important updated information on fracture incidence trends and cost,
data which have been essential for quantifying the public health burden of osteoporosis nationally. These
studies are possible due to the unique resources of the Rochester Epidemiology Project, a medical records
linkage system which provides access to detailed medical data for an entire geographically-defined
population, and the Olmsted County Healthcare Expenditure and Utilization Database, which estimates the
cost of all outpatient and inpatient medical care delivered to local residents. Our choice of aims for this
funding cycle is especially relevant in light of the new World Health Organization approach to fracture risk
assessment, which identifies rheumatoid arthritis (RA) and personal fracture history as key risk factors.
Since our preliminary data suggest that most RA patients will not fracture over their remaining lifetimes, we
not only will characterize high risk individuals, but also those at low risk for fracture who might be spared
costly osteoporosis treatment. Furthermore, fractures occurring before age 40 years are presently ignored in
osteoporosis risk assessment so we will use novel technologies to determine if those who suffered a forearm
fracture in childhood (the most common fracture in youth) have deficits in bone metabolism, structure, or
strength that persist into adulthood, as some have suggested, and whether they are at increased risk for
fractures in later life. The descriptive incidence and cost data for fractures at all skeletal sites are needed for
related policy determinations (e.g., cost-effectiveness of fracture prophylaxis). The population-based studies
proposed will therefore fill important gaps in our knowledge of age-related fracture risk.
RELEVANCE (See instructions):
Because the aging population is increasingly at risk of devastating osteoporotic fractures, it is important to
identify high-risk individuals for more aggressive osteoporosis management, while also characterizing lowrisk
individuals who might appropriately be spared treatment expense and side effects. Updated information
on fracture frequency and cost is needed to help define the most efficient approaches to fracture prevention.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
BONE DENSITY AMONG OLMSTED COUNTY RESIDENTS FROM CAMBODIA
-
批准号:6264992
-
项目类别:
-
资助金额:$2.01万
-
财政年份:1998
-
负责人:L. JOSEPH MELTON
-
依托单位:
BONE DENSITY AMONG AFRICAN AMERICAN RESIDENTS OF OLMSTED COUNTY
-
批准号:6264994
-
项目类别:
-
资助金额:$2.01万
-
财政年份:1998
-
负责人:L. JOSEPH MELTON
-
依托单位:
BONE MINERAL DENSITY MEASUREMENT IN ADULT SOMALI POPULATION
-
批准号:6264965
-
项目类别:
-
资助金额:$2.01万
-
财政年份:1998
-
负责人:L. JOSEPH MELTON
-
依托单位:
ROCHESTER EPIDEMIOLOGY PROJECT
-
批准号:2078697
-
项目类别:
-
资助金额:$38.17万
-
财政年份:1995
-
负责人:L. JOSEPH MELTON
-
依托单位:
ROCHESTER EPIDEMIOLOGY PROJECT
-
批准号:2769557
-
项目类别:
-
资助金额:$38.98万
-
财政年份:1995
-
负责人:L. JOSEPH MELTON
-
依托单位:
ROCHESTER EPIDEMIOLOGY PROJECT
-
批准号:2078698
-
项目类别:
-
资助金额:$36.87万
-
财政年份:1995
-
负责人:L. JOSEPH MELTON
-
依托单位:
ROCHESTER EPIDEMIOLOGY PROJECT
-
批准号:2517428
-
项目类别:
-
资助金额:$38.07万
-
财政年份:1995
-
负责人:L. JOSEPH MELTON
-
依托单位:
ROCHESTER EPIDEMIOLOGY PROJECT
-
批准号:6055561
-
项目类别:
-
资助金额:$40.22万
-
财政年份:1995
-
负责人:L. JOSEPH MELTON
-
依托单位:
BREAST CANCER RISK ASSESSMENT IN BENIGN BREAST DISEASE
-
批准号:3189586
-
项目类别:
-
资助金额:$19.08万
-
财政年份:1987
-
负责人:L. JOSEPH MELTON
-
依托单位:
BREAST CANCER RISK ASSESSMENT IN BENIGN BREAST DISEASE
-
批准号:3189584
-
项目类别:
-
资助金额:$17.66万
-
财政年份:1987
-
负责人:L. JOSEPH MELTON
-
依托单位:
BREAST CANCER RISK ASSESSMENT IN BENIGN BREAST DISEASE
-
批准号:3189585
-
项目类别:
-
资助金额:$20.75万
-
财政年份:1987
-
负责人:L. JOSEPH MELTON
-
依托单位:
ROCHESTER EPIDEMIOLOGY PROJECT
-
批准号:2078696
-
项目类别:
-
资助金额:$42.93万
-
财政年份:1981
-
负责人:L. JOSEPH MELTON
-
依托单位:
ROCHESTER EPIDEMIOLOGY PROJECT
-
批准号:3155840
-
项目类别:
-
资助金额:$28.21万
-
财政年份:1981
-
负责人:L. JOSEPH MELTON
-
依托单位:
ROCHESTER EPIDEMIOLOGY PROJECT
-
批准号:3155845
-
项目类别:
-
资助金额:$30.57万
-
财政年份:1981
-
负责人:L. JOSEPH MELTON
-
依托单位:
ROCHESTER EPIDEMIOLOGY PROJECT
-
批准号:3155846
-
项目类别:
-
资助金额:$41.57万
-
财政年份:1981
-
负责人:L. JOSEPH MELTON
-
依托单位:
EPIDEMIOLOGY OF AGE RELATED BONE LOSS & FRACTURE
-
批准号:3155501
-
项目类别:
-
资助金额:$37.43万
-
财政年份:1980
-
负责人:L. JOSEPH MELTON
-
依托单位:
EPIDEMIOLOGY OF AGE RELATED BONE LOSS & FRACTURE
-
批准号:3155503
-
项目类别:
-
资助金额:$43.7万
-
财政年份:1980
-
负责人:L. JOSEPH MELTON
-
依托单位:
EPIDEMIOLOGY OF AGE RELATED BONE LOSS & FRACTURE
-
批准号:3155502
-
项目类别:
-
资助金额:$39.02万
-
财政年份:1980
-
负责人:L. JOSEPH MELTON
-
依托单位:
EPIDEMIOLOGY OF AGE RELATED BONE LOSS AND FRACTURES
-
批准号:6016868
-
项目类别:
-
资助金额:$52.77万
-
财政年份:1980
-
负责人:L. JOSEPH MELTON
-
依托单位:
EPIDEMIOLOGY OF AGE RELATED BONE LOSS AND FRACTURES
-
批准号:2712432
-
项目类别:
-
资助金额:$51.17万
-
财政年份:1980
-
负责人:L. JOSEPH MELTON
-
依托单位:
海外基金