ROCHESTER EPIDEMIOLOGY PROJECT

罗彻斯特流行病学项目

• 批准号: 2769557
• 负责人: L. JOSEPH MELTON
• 金额: $ 38.98万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-07 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2769557
• 关键词: arthritis; automated medical record system; cancer registry /resource; cardiovascular disorder epidemiology; computer data analysis; dementia; diabetes mellitus; epidemiology; gastrointestinal disorder; genetic registry /resource /referral center; human population genetics; human subject; indexing; longitudinal human study; neoplasm /cancer epidemiology; neoplasm /cancer genetics; nervous system disorder epidemiology; osteoporosis; patient /disease registry; postmortem; statistics /biometry; stroke

DESCRIPTION: (Adapted from Applicant's Abstract) The Rochester Epidemiology Project (REP) is the medical records linkage system that encompasses the care delivered to residents of Rochester and Olmsted County, Minnesota. By affording access to the detailed inpatient and outpatient medical records of health care providers in the community, this unique data resource is able to provide accurate incidence and trend data over 50 years or more for nearly any disease or syndrome and to support population-based studies of etiology and outcome. It makes possible the efficient implementation of important studies on the epidemiology of heart disease, stroke, dementia, cancer, diabetes, digestive diseases, osteoporosis, arthritis and other disorders that have culminated in 813 publications since the system was organized in 1966 including 353 (261 published; 92 accepted or submitted) in the past four years. Although Mayo Clinic contributes substantially to the support of this database by indexing the medical events cited in its own records at no cost to this project, ongoing extramural support is needed to collect diagnostic data from the non-Mayo providers in the community and to integrate the information from all sources of care into a true population-based data repository. Specifically, continued funding is needed to: (1) enhance and maintain the enumeration and unique identification of Olmsted County residents which serves as the essential core of this data system; (2) continue collecting medical event data (e.g., diagnoses, procedures) from the non-Mayo providers of health care for 1995 through 1999 in order to ensure complete case ascertainment and follow-up; (3) complete and maintain the REP Master file (the relational database which will provide electronic linkage of medical events with the enumerated population of the county) and to begin integrating the increasing volume of electronic information about episodes of medical care and hospitalization, clinical and pathological diagnoses, surgical and diagnostic procedures, laboratory values, prescription drugs and data from specific study files or registries into this database; and (4) improve logistic support for epidemiologic studies by further automating study procedures and by developing additional analytic tools. These activities are indispensable to the continued support of the large body of epidemiologic research that is being conducted in this population by investigators from Mayo Clinic and other centers throughout the country, including 20 separate studies funded by the National Institutes of Health during the previous grant period. These studies have served to increase knowledge of a multitude of disease processes of social significance nationally. Although the basic data system has worked well, these aims will allow the investigators to extend the capabilities of this research infrastructure and to further validate the Rochester Epidemiology Project databases and investigative approaches.

描述：（改编自申请人的摘要）罗切斯特 流行病学项目（REP）是医疗记录链接系统， 包括为罗切斯特和奥姆斯特德的居民提供的护理 明尼苏达州，县。 通过提供详细的住院病人和 社区卫生保健提供者的门诊病历， 这种独特的数据资源能够提供准确的发病率， 几乎任何疾病或综合征的50年或更长时间的趋势数据， 以支持基于人群的病因学和结局研究。 它使 可能有效地执行关于 心脏病、中风、痴呆、癌症、糖尿病、 消化系统疾病，骨质疏松症，关节炎和其他疾病， 自1966年该系统成立以来，共出版了813份出版物 包括过去四年的353项（261项已发表; 92项已接受或提交） 年 虽然马约诊所为支持 该数据库通过索引其自身记录中引用的医疗事件 在没有成本，这个项目，持续的校外支持是必要的， 从社区的非梅奥提供者那里收集诊断数据， 将来自所有护理来源的信息整合成一个真正的 基于人口的数据库。 具体而言，持续供资是 需要：（1）加强和维护枚举和独特的 奥姆斯特德县居民的身份，作为基本的 该数据系统的核心;（2）继续收集医疗事件数据 (e.g.,诊断，程序）从非梅奥医疗保健提供者 以确保彻底查明案件， 跟进;（3）完成和维护REP主文件（关系 该数据库将提供医疗事件与 县的人口），并开始整合 关于医疗事件的电子信息量不断增加 护理和住院、临床和病理诊断、外科手术 诊断程序、实验室值、处方药和数据 从特定的研究文件或登记册中检索到该数据库中;以及（4） 通过进一步自动化改善流行病学研究的后勤支持 研究程序和开发额外的分析工具。 这些 这些活动对于继续支持这一庞大机构是必不可少的 在这个人群中进行的流行病学研究， 来自马约诊所和全国其他中心的调查人员， 包括由美国国立卫生研究院资助的20项独立研究， 在上一个补助期。 这些研究有助于增加 对具有社会意义的多种疾病过程的了解 全国范围内。 虽然基本数据系统运行良好，但这些目标 将使研究人员能够扩展这项研究的能力， 基础设施，并进一步验证罗切斯特流行病学项目 数据库和调查方法。