REGULATION OF CYCLIN C FUNCTION IN TUMORS & NORMAL CELLS

肿瘤中细胞周期蛋白 C 功能的调节

• 批准号: 2010643
• 负责人: JILL M LAHTI
• 金额: $ 9.38万
• 依托单位: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-01 至 2002-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2010643
• 关键词: RNA splicing; Sf9 cell line; cell growth regulation; chickens; cyclins; enzyme activity; gene targeting; messenger RNA; neoplastic cell; polymerase chain reaction; protein kinase; protein structure function; transfection /expression vector; western blottings

DESCRIPTION (adapted from investigator's abstract): The role of cyclin C in cell cycle regulation is currently poorly characterized. Cyclin C was isolated as a gene which can rescue G1 cyclin nulls in yeast indicating it can complement G1 cyclin function. Cyclin C interacts with cdk8 and by homology with cdc8 this suggests it may regulate RNA polymerase activity. However, this function is inconsistent with the rescue results which indicate a more direct role of cyclin C in cell cycle regulation. The cyclin C gene in humans maps to chromosome position in the 6q 21 region. Importantly, Dr. Lahti has shown that in 80% of childhood acute lymphoblastic leukemias cyclin C is deleted suggesting a causal relationship between cyclin C deletion and transformation in these tumors.

描述（改编自研究者摘要）：细胞周期蛋白C在 细胞周期调节目前的特征很差。 Cyclin C是 分离出一个基因，它可以拯救酵母中的G1期细胞周期蛋白空值，这表明它 可以补充G1细胞周期蛋白的功能。 细胞周期蛋白C与cdk 8相互作用， 与cdc8同源，这表明它可能调节RNA聚合酶活性。 然而，这一功能与救援结果不一致， 表明细胞周期蛋白C在细胞周期调节中更直接作用。 的 人类细胞周期蛋白C基因定位于6 q 21区域的染色体位置。 重要的是，拉赫蒂博士已经表明，在80%的儿童急性 淋巴母细胞白血病细胞周期蛋白C缺失提示因果关系 在这些肿瘤中细胞周期蛋白C缺失和转化之间的关系。