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REGULATION OF CYCLIN C FUNCTION IN TUMORS & NORMAL CELLS

REGULATION OF CYCLIN C FUNCTION IN TUMORS & NORMAL CELLS
肿瘤中细胞周期蛋白 C 功能的调节
批准号：
2010643
负责人：
JILL M LAHTI
金额：
$9.38万
依托单位：
ST. JUDE CHILDREN'S RESEARCH HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-03-01 至 2002-02-28
来源：
https://reporter.nih.gov/project-details/2010643
关键词：
RNA splicing Sf9 cell line cell growth regulation chickens cyclins enzyme activity gene targeting messenger RNA neoplastic cell polymerase chain reaction protein kinase protein structure function transfection /expression vector western blottings

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DESCRIPTION (adapted from investigator's abstract): The role of cyclin C in cell cycle regulation is currently poorly characterized. Cyclin C was isolated as a gene which can rescue G1 cyclin nulls in yeast indicating it can complement G1 cyclin function. Cyclin C interacts with cdk8 and by homology with cdc8 this suggests it may regulate RNA polymerase activity. However, this function is inconsistent with the rescue results which indicate a more direct role of cyclin C in cell cycle regulation. The cyclin C gene in humans maps to chromosome position in the 6q 21 region. Importantly, Dr. Lahti has shown that in 80% of childhood acute lymphoblastic leukemias cyclin C is deleted suggesting a causal relationship between cyclin C deletion and transformation in these tumors.
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REGULATION OF CYCLIN C FUNCTION IN TUMORS & NORMAL CELLS