REGULATION OF CYCLIN C FUNCTION IN TUMORS & NORMAL CELLS

描述（改编自研究者摘要）：细胞周期蛋白C在 细胞周期调节目前的特征很差。 Cyclin C是 分离出一个基因，它可以拯救酵母中的G1期细胞周期蛋白空值，这表明它 可以补充G1细胞周期蛋白的功能。 细胞周期蛋白C与cdk 8相互作用， 与cdc8同源，这表明它可能调节RNA聚合酶活性。 然而，这一功能与救援结果不一致， 表明细胞周期蛋白C在细胞周期调节中更直接作用。 的 人类的细胞周期蛋白C基因定位于染色体6q21区域。 重要的是，拉赫蒂博士已经表明，在80%的儿童急性 淋巴母细胞白血病细胞周期蛋白C缺失提示因果关系 在这些肿瘤中细胞周期蛋白C缺失和转化之间的关系。

DESCRIPTION (adapted from investigator's abstract): The role of cyclin C in cell cycle regulation is currently poorly characterized. Cyclin C was isolated as a gene which can rescue G1 cyclin nulls in yeast indicating it can complement G1 cyclin function. Cyclin C interacts with cdk8 and by homology with cdc8 this suggests it may regulate RNA polymerase activity. However, this function is inconsistent with the rescue results which indicate a more direct role of cyclin C in cell cycle regulation. The cyclin C gene in humans maps to chromosome position in the 6q 21 region. Importantly, Dr. Lahti has shown that in 80% of childhood acute lymphoblastic leukemias cyclin C is deleted suggesting a causal relationship between cyclin C deletion and transformation in these tumors.