REGULATION OF CYCLIN C FUNCTION IN TUMORS & NORMAL CELLS

肿瘤中细胞周期蛋白 C 功能的调节

• 批准号: 2668059
• 负责人: JILL M LAHTI
• 金额: $ 9.75万
• 依托单位: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-01 至 2002-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2668059
• 关键词: RNA splicing; Sf9 cell line; cell growth regulation; chickens; cyclins; enzyme activity; gene targeting; messenger RNA; neoplastic cell; polymerase chain reaction; protein kinase; protein structure function; transfection /expression vector; western blottings

DESCRIPTION (adapted from investigator's abstract): The role of cyclin C in cell cycle regulation is currently poorly characterized. Cyclin C was isolated as a gene which can rescue G1 cyclin nulls in yeast indicating it can complement G1 cyclin function. Cyclin C interacts with cdk8 and by homology with cdc8 this suggests it may regulate RNA polymerase activity. However, this function is inconsistent with the rescue results which indicate a more direct role of cyclin C in cell cycle regulation. The cyclin C gene in humans maps to chromosome position in the 6q 21 region. Importantly, Dr. Lahti has shown that in 80% of childhood acute lymphoblastic leukemias cyclin C is deleted suggesting a causal relationship between cyclin C deletion and transformation in these tumors.

描述（改编自研究者摘要）：细胞周期蛋白C在