REGULATION OF CYCLIN C FUNCTION IN TUMORS & NORMAL CELLS

描述(改编自研究人员摘要)：细胞周期蛋白C在 目前对细胞周期调控的研究还不多见。Cyclin C是 在酵母中分离出一种可以拯救G1周期蛋白缺失的基因，表明它是 可补充G1期细胞周期蛋白功能。细胞周期蛋白C与CDK8相互作用 与cdc8的同源性表明它可能调节RNA聚合酶的活性。 然而，这一功能与救援结果不一致 提示细胞周期蛋白C在细胞周期调控中有更直接的作用。这个 人类细胞周期蛋白C基因定位于染色体6q21区域。 重要的是，拉赫蒂博士已经表明，在80%的儿童急性 淋巴母细胞白血病细胞周期蛋白C缺失提示两者之间存在因果关系 这些肿瘤中细胞周期蛋白C缺失与转化的关系。

DESCRIPTION (adapted from investigator's abstract): The role of cyclin C in cell cycle regulation is currently poorly characterized. Cyclin C was isolated as a gene which can rescue G1 cyclin nulls in yeast indicating it can complement G1 cyclin function. Cyclin C interacts with cdk8 and by homology with cdc8 this suggests it may regulate RNA polymerase activity. However, this function is inconsistent with the rescue results which indicate a more direct role of cyclin C in cell cycle regulation. The cyclin C gene in humans maps to chromosome position in the 6q 21 region. Importantly, Dr. Lahti has shown that in 80% of childhood acute lymphoblastic leukemias cyclin C is deleted suggesting a causal relationship between cyclin C deletion and transformation in these tumors.