ICER AND NORMAL AND NEOPLASTIC CELL GROWTH

ICER 与正常细胞和肿瘤细胞生长

• 批准号: 2443221
• 负责人: CARLOS A MOLINA
• 金额: $ 10.12万
• 依托单位: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-15 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2443221
• 关键词: athymic mouse; cell growth regulation; gene expression; neoplastic growth; neoplastic transformation; phosphorylation; tissue /cell culture; transcription factor

DESCRIPTION (Adapted from the applicant's abstract): These data support the working hypothesis that ICER functions as an antioncogene in mammalian cells, since its expression decelerates the uncontrollable cell growth which is characteristic of malignant cells. To test this hypothesis, the following specific aims are proposed: 1) to further characterize the role of ICERIIgamma in the AtT20 cell cycle, 2) to determine the role of ICERIIgamma in cell growth, proliferation and the process of oncogenesis, and 3) to determine whether ICERIIgamma activity is regulated by phosphorylation. These aims will be achieved by assessment of the effects of overexpression of ICERIIgamma in specific mammalian cell systems. Completion of these aims will allow a more comprehensive understanding of the role played by the cAMP pathway and the CREM gene in cell growth, differentiation and tumorigenesis. These results will therefore have a significant impact upon understanding of proliferation of normal and neoplastic cells.

描述（改编自申请人的摘要）：这些数据支持