ICER AND NORMAL AND NEOPLASTIC CELL GROWTH

ICER 与正常细胞和肿瘤细胞生长

• 批准号: 6083282
• 负责人: CARLOS A MOLINA
• 金额: $ 1.08万
• 依托单位: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-15 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6083282
• 关键词: athymic mouse; cell growth regulation; gene expression; neoplastic growth; neoplastic transformation; phosphorylation; tissue /cell culture; transcription factor

DESCRIPTION (Adapted from the applicant's abstract): These data support the working hypothesis that ICER functions as an antioncogene in mammalian cells, since its expression decelerates the uncontrollable cell growth which is characteristic of malignant cells. To test this hypothesis, the following specific aims are proposed: 1) to further characterize the role of ICERIIgamma in the AtT20 cell cycle, 2) to determine the role of ICERIIgamma in cell growth, proliferation and the process of oncogenesis, and 3) to determine whether ICERIIgamma activity is regulated by phosphorylation. These aims will be achieved by assessment of the effects of overexpression of ICERIIgamma in specific mammalian cell systems. Completion of these aims will allow a more comprehensive understanding of the role played by the cAMP pathway and the CREM gene in cell growth, differentiation and tumorigenesis. These results will therefore have a significant impact upon understanding of proliferation of normal and neoplastic cells.

描述（改编自申请人摘要）：这些数据支持 ICER在哺乳动物中作为抗癌基因发挥作用的工作假说 细胞，因为它的表达减缓了无法控制的细胞生长， 是恶性细胞的特征 为了验证这一假设， 提出了以下具体目标：1）进一步确定 ICERII γ在AtT20细胞周期中的作用，2）确定ICERII γ在AtT20细胞周期中的作用， ICERII γ在细胞生长、增殖和肿瘤发生过程中的作用， 和3）确定ICERII γ活性是否受以下因素调节： 磷酸化 这些目标将通过评估效果来实现 ICERII γ在特定哺乳动物细胞系统中的过度表达。 这些目标的完成将使我们能够更全面地了解 cAMP途径和CREM基因在细胞生长中的作用， 分化和肿瘤发生。 因此，这些结果将具有 对理解正常和 肿瘤细胞