ICER AND NORMAL AND NEOPLASTIC CELL GROWTH
ICER AND NORMAL AND NEOPLASTIC CELL GROWTH
批准号:
6320151
负责人:
CARLOS A MOLINA
金额:
$1.08万
依托单位国家:
美国
项目类别:
财政年份:
1996
资助国家:
美国
项目状态:
已结题
起止时间:
1996-09-15 至 2002-11-30
中文摘要
描述(改编自申请人摘要):这些数据支持
ICER在哺乳动物中作为抗癌基因发挥作用的工作假说
细胞,因为它的表达减缓了无法控制的细胞生长,
是恶性细胞的特征 为了验证这一假设,
提出了以下具体目标:1)进一步确定
ICERII γ在AtT20细胞周期中的作用,2)确定ICERII γ在AtT20细胞周期中的作用,
ICERII γ在细胞生长、增殖和肿瘤发生过程中的作用,
和3)确定ICERII γ活性是否受以下因素调节:
磷酸化 这些目标将通过评估效果来实现
ICERII γ在特定哺乳动物细胞系统中的过度表达。
这些目标的完成将使我们能够更全面地了解
cAMP途径和CREM基因在细胞生长中的作用,
分化和肿瘤发生。 因此,这些结果将具有
对理解正常和
肿瘤细胞
英文摘要
DESCRIPTION (Adapted from the applicant's abstract): These data support the
working hypothesis that ICER functions as an antioncogene in mammalian
cells, since its expression decelerates the uncontrollable cell growth which
is characteristic of malignant cells. To test this hypothesis, the
following specific aims are proposed: 1) to further characterize the role
of ICERIIgamma in the AtT20 cell cycle, 2) to determine the role of
ICERIIgamma in cell growth, proliferation and the process of oncogenesis,
and 3) to determine whether ICERIIgamma activity is regulated by
phosphorylation. These aims will be achieved by assessment of the effects
of overexpression of ICERIIgamma in specific mammalian cell systems.
Completion of these aims will allow a more comprehensive understanding of
the role played by the cAMP pathway and the CREM gene in cell growth,
differentiation and tumorigenesis. These results will therefore have a
significant impact upon understanding of proliferation of normal and
neoplastic cells.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Post-translational Regulation of Inducible cAMP Early Repressor and its Implications in Cancer
-
批准号:9922968
-
项目类别:
-
资助金额:$32.12万
-
财政年份:2018
-
负责人:CARLOS A MOLINA
-
依托单位:
Inducible cAMP Early Repressor in ovarian function.
-
批准号:6836070
-
项目类别:
-
资助金额:$7.75万
-
财政年份:2003
-
负责人:CARLOS A MOLINA
-
依托单位:
Inducible cAMP Early Repressor in ovarian function
-
批准号:6708136
-
项目类别:
-
资助金额:$7.75万
-
财政年份:2003
-
负责人:CARLOS A MOLINA
-
依托单位:
ICER AND NORMAL AND NEOPLASTIC CELL GROWTH
-
批准号:6594163
-
项目类别:
-
资助金额:$5.6万
-
财政年份:1996
-
负责人:CARLOS A MOLINA
-
依托单位:
ICER AND NORMAL AND NEOPLASTIC CELL GROWTH
-
批准号:2443221
-
项目类别:
-
资助金额:$10.12万
-
财政年份:1996
-
负责人:CARLOS A MOLINA
-
依托单位:
ICER AND NORMAL AND NEOPLASTIC CELL GROWTH
-
批准号:2009160
-
项目类别:
-
资助金额:$9.27万
-
财政年份:1996
-
负责人:CARLOS A MOLINA
-
依托单位:
ICER AND NORMAL AND NEOPLASTIC CELL GROWTH
-
批准号:6083282
-
项目类别:
-
资助金额:$1.08万
-
财政年份:1996
-
负责人:CARLOS A MOLINA
-
依托单位:
ICER AND NORMAL AND NEOPLASTIC CELL GROWTH
-
批准号:2895448
-
项目类别:
-
资助金额:$12.05万
-
财政年份:1996
-
负责人:CARLOS A MOLINA
-
依托单位:
ICER AND NORMAL AND NEOPLASTIC CELL GROWTH
-
批准号:6173346
-
项目类别:
-
资助金额:$13.16万
-
财政年份:1996
-
负责人:CARLOS A MOLINA
-
依托单位:
ICER AND NORMAL AND NEOPLASTIC CELL GROWTH
-
批准号:2733200
-
项目类别:
-
资助金额:$11.04万
-
财政年份:1996
-
负责人:CARLOS A MOLINA
-
依托单位:
NIH INTRAMURAL NRSA INSTITUTIONAL TRAINING PROGRAM
-
批准号:2129154
-
项目类别:
-
资助金额:$2.06万
-
财政年份:1993
-
负责人:CARLOS A MOLINA
-
依托单位:
NIH INTRAMURAL-NRSA INSTITUTIONAL TRAINING PROGRAM
-
批准号:2129155
-
项目类别:
-
资助金额:$1.57万
-
财政年份:1993
-
负责人:CARLOS A MOLINA
-
依托单位:
MECHANISMS OF CARCINOGENESIS
-
批准号:3024714
-
项目类别:
-
资助金额:$1.3万
-
财政年份:1989
-
负责人:CARLOS A MOLINA
-
依托单位:
MECHANISMS OF CARCINOGENESIS
-
批准号:3024713
-
项目类别:
-
资助金额:$1.09万
-
财政年份:1988
-
负责人:CARLOS A MOLINA
-
依托单位:
MECHANISMS OF CARCINOGENESIS
-
批准号:3024712
-
项目类别:
-
资助金额:$1.53万
-
财政年份:1987
-
负责人:CARLOS A MOLINA
-
依托单位:
MECHANISMS OF CARCINOGENESIS
-
批准号:3024711
-
项目类别:
-
资助金额:$1.5万
-
财政年份:1986
-
负责人:CARLOS A MOLINA
-
依托单位:
海外基金