FAMILIAL AGGREGATION AND COAGGREGATION OF CANCER

描述：(改编自申请人摘要)：建议 研究是对与家庭有关的癌症风险的系统检查。 癌症病史以大量人群为基础的家谱。很明显，从 大量的流行病学和遗传学研究表明，许多人的家族史 各种癌症会增加一个人患癌症的风险，在几种情况下 特定基因的突变已被鉴定为与 家族性癌综合征。然而，对于绝大多数癌症来说， 遗传易感性对癌症风险的特定贡献并没有 描述得很好。我们建议研究与以下因素相关的癌症风险 通过以下途径确定的大量人群的癌症家族史 犹他州人口数据库(UPDB)，包含谱系的资源 关于100多万个个体的长达六代的信息。这个 家谱记录持续地链接到 犹他州癌症登记中心，自那以来记录了犹他州诊断出的所有癌症 1966年。我们将研究其他方法来估计家庭成员 癌症汇总、估计相关的相对风险和归因风险 有36种不同癌症的家族史，并检查 癌症的家族聚集型。为了实现这些目标 目标，我们将在UPDB中纳入新的后续信息，我们将 使数据库的所有用户都可以使用。

DESCRIPTION: (Adapted from the Applicant's Abstract): The proposed research is a systematic examination of cancer risk in relation to family history of cancer in a large population-based genealogy. It is clear from numerous epidemiologic and genetic studies that a family history of many kinds of cancer increases a person's risk of cancer, and in several cases mutations of particular genes have been identified that are associated with familial cancer syndromes. However, for the vast majority of cancers, the specific contributions of inherited predisposition to cancer risk have not been well described. We propose to examine cancer risk associated with family histories of cancer in a large cohort of people identified through the Utah Population Database (UPDB), a resource that contains pedigree information up to six generations deep on over one million individuals. The genealogy records are linked on a continuing basis to the records of the Utah Cancer Registry, which has recorded all cancers diagnosed in Utah since 1966. We will examine alternative methods for estimating familial aggregation of cancer, estimate relative and attributable risks associated with family history for 36 different kinds of cancer, and examine the patterns of familial coaggregation of cancer. In order to accomplish these goals, we will incorporate new follow-up information into UPDB that we will make available to all users of the database.