FAMILIAL AGGREGATION AND COAGGREGATION OF CANCER

描述：（改编自申请人的摘要）： 癌症研究是对癌症风险与家庭关系的系统检查， 癌症史在一个大的人口为基础的家谱。 清楚地表明 大量的流行病学和遗传学研究表明， 多种癌症会增加一个人患癌症的风险，在某些情况下， 特定基因的突变已经被确定与 家族性癌症综合征 然而，对于绝大多数癌症， 遗传易感性对癌症风险的具体贡献还没有 被描述得很好。 我们建议检查与以下因素相关的癌症风险： 在一个大型队列中，通过以下方法确定了癌症家族史： 犹他州人口数据库（UTB），一个包含系谱的资源 超过一百万个体的六代信息。 的 家谱记录在持续的基础上与 犹他州癌症登记处，该登记处记录了自2010年以来犹他州诊断出的所有癌症。 1966. 我们将研究估计家族性的替代方法， 癌症的聚集，估计相关的相对和归因风险 有36种不同癌症的家族史，并检查 癌症的家族聚集模式。 为了完成这些 目标，我们将把新的后续信息纳入CQB， 向数据库的所有用户提供。

DESCRIPTION: (Adapted from the Applicant's Abstract): The proposed research is a systematic examination of cancer risk in relation to family history of cancer in a large population-based genealogy. It is clear from numerous epidemiologic and genetic studies that a family history of many kinds of cancer increases a person's risk of cancer, and in several cases mutations of particular genes have been identified that are associated with familial cancer syndromes. However, for the vast majority of cancers, the specific contributions of inherited predisposition to cancer risk have not been well described. We propose to examine cancer risk associated with family histories of cancer in a large cohort of people identified through the Utah Population Database (UPDB), a resource that contains pedigree information up to six generations deep on over one million individuals. The genealogy records are linked on a continuing basis to the records of the Utah Cancer Registry, which has recorded all cancers diagnosed in Utah since 1966. We will examine alternative methods for estimating familial aggregation of cancer, estimate relative and attributable risks associated with family history for 36 different kinds of cancer, and examine the patterns of familial coaggregation of cancer. In order to accomplish these goals, we will incorporate new follow-up information into UPDB that we will make available to all users of the database.