NOVEL ANTIGENS FOR THE SERODIAGNOSIS OF HUMAN BABESIOSIS

描述(改编自申请人的摘要)：本提案 讨论了多肽/重组蛋白的生产和实施 用于建立诊断流行性出血热的血清学试验的抗原 人类巴贝斯虫病，一种由壁虱传播的疾病。加强对扁虱的监测 媒介感染表明，许多感染莱姆病的人 疾病与微小巴贝斯虫(人类病原体)混合感染 巴贝斯虫病)和埃利希氏菌，这两种细菌在 任何免疫受损的人都可能影响输血。自.以来 微小球虫感染(类疟疾红细胞内感染)的治疗 寄生虫)与莱姆病有很大的不同，需要一种 准确的血清学测试以鉴别这两种感染。B.microti 特定的多肽/重组体将单独或联合使用来 开发一种检测方法来补充目前可用的莱姆病检测。 用于诊断的微小芽孢杆菌特异性抗原的研制 提高我们检测扁虱传播疾病的能力，并促进 给予适当的治疗。预付款已经是 Corixa在鉴定免疫优势重组抗原方面取得的成就。 这一点与与关键研究人员在 扁虱传播疾病的地区和获得广泛的血清库的机会 通过在其他传染病项目上的工作积累起来的 使本提案的目的和目的得以实现。

DESCRIPTION (Adapted from the Applicant's Abstract): This proposal discusses the production and implementation of peptide/recombinant antigens for the development of a serological assay for the diagnosis of human babesiosis, a tick-borne disease. Increased surveillance of tick borne infections has shown that many individuals infected with Lyme disease have co-infections with Babesia microti (agent of human babesiosis) and Ehrlichia both of which are potentially fatal in immunocompromised individuals any may impact blood transfusions. Since the treatment of B. microti infections (malaria-like intraerythrocytic parasite) is vastly different to Lyme disease there is a need for an accurate serology test to differentiate the two infections. B. microti specific peptides/recombinants will be used alone or in combination to develop an assay to supplement the currently available Lyme disease test. Development of specific antigens for B. microti for use in diagnosis improves our ability to detect tick-borne diseases and facilitates administration of the appropriate treatment. Advances have already been achieved at Corixa in identifying immunodominant recombinant antigens. This in combination with a collaboration with key investigator in the area of tick-borne diseases and access to an extensive serum bank accumulated through work on other infectious disease programs should enable the goals and objectives of this proposal to be achieved.