DEVELOPMENT OF SIMULATIONS TO DETECT IMPAIRED DRIVERS

HIV感染的神经心理学后遗症包括 注意力/信息处理速度，执行技能，学习， 和感知运动功能，这些能力是必要的， 熟练的汽车驾驶。个体NP 然而，损伤预测不安全驾驶尚不清楚， 健身驾驶是困难的，因为医生经常有不足的， 数据和道路上的评估通常不允许评估， 紧急情况。该项目旨在开发驾驶模拟 对受损的驾驶能力很敏感， 在一个经济实惠的，基于PC的系统上。我们将设计两个模拟： 将评估日常驾驶和事故避免，另一个将 由一个新的，“虚拟城市”，其中病人是计划， 执行一个驱动器通过社区到一个目标位置。使用艾滋病毒- 感染受试者，我们将评估这些评估的可靠性， 通过比较受试者的模拟器性能（1）来验证措施 有和没有最近的汽车事故和（2）在路上 试验.由于驾驶技术可能会受到常见的处方 药物，酒精和其他娱乐性药物，以及中枢神经系统 许多病因的系统疾病，预计这 技术将广泛适用于神经行为研究， 司机评价 拟定商业应用： 低成本驾驶模拟器技术从未系统地 验证.这里提出的模拟器将被验证并用于 收集规范性数据，可应用于所有需要 安全了真实的世界驾驶环境。潜在市场包括评估 受损的司机。驾驶员培训和康复（酒精，毒品， 头部损伤、残疾、中风等），司机教育。

The neuropsychological (NP) sequelae of HIV infection include impairment in attention/speed of information processing, executive skills, learning, and perceptual-motor functioning, abilities which are necessary for competent automobile driving. The degree to which individual NP impairments predict unsafe driving is unclear, however, and determining fitness to drive is difficult, since physicians frequently have inadequate data and on-the-road assessments usually do not allow evaluation under emergency conditions. This project aims to develop driving simulations that are sensitive to impaired driving abilities and can be administered on an affordable, PC-based system. We will design two simulations: one will assess routine driving and accident avoidance, and the other will consist of a novel, "virtual city", in which the patient is to plan and execute a drive through neighborhoods to a target location. Using HIV- infected subjects, we will assess the reliability of these assessments and validate the measures by comparing simulator performance (1) in subjects with and without recent automobile accidents and (2) with on-the-road testing. Since driving skills may be affected by commonly-prescribed medications, alcohol and other recreational drugs, and central nervous system disorders of many etiologies, it is anticipated that this technology will have broad applicability for neurobehavioral research and driver assessments. PROPOSED COMMERCIAL APPLICATION: Low cost driving simulator technology has never been systematically validated. The simulator proposed here will be validated and used to collect normative data that can be applied to all areas that require a safe. real world driving environment. Potential markets include assessment of impaired drivers. driver training and rehabilitation (alcohol, drugs, head injuries, disabilities, strokes, etc.), and driver education.