CONTROL OF ETHANOL INGESTION BY CONDITIONED REINFORCERS

条件反射剂（CSR）涉及调节药物- 强化行为。 条件反射与 乙醇摄入量尚未得到广泛研究。 证据表明 乙醇相关的中性刺激可以获得强化特性。 乙醇和CSR都受到中脑边缘多巴胺系统的影响。 它 假设通过将中性刺激与 口服乙醇自我给药将影响启动和 维持一个乙醇回合和中脑边缘多巴胺系统将 调节两种减毒剂的功效。 这一假设将是 采用操作性技术检测（1）口腔自我能力， 给予乙醇以建立CSR，（2）CSR在 启动和维持乙醇消耗，以及（3）调节 中脑边缘多巴胺在乙醇和CSR强化中的作用。 调节 强化将通过中性刺激的维持能力来评估 在操作性灭绝中做出反应 答复率的变化 CSR的存在和不存在将用于评估其在以下方面的作用： 启动和维持乙醇自我给药。 显微注射 在灭绝期之前注入了大量的安非他明 将用于评估中脑边缘多巴胺在这些过程中的作用。 研究CSR在乙醇强化中的作用将为我们提供深入了解 他们对维持过度的乙醇消费的贡献 然后释放

Conditioned reinforcers (CSR) have been implicated in modulating drug- reinforced behaviors. The relationship between conditioned reinforcers and ethanol intake has not been extensively studied. Evidence suggests that ethanol-associated neutral stimuli can acquire reinforcing properties. Ethanol and CSR are both influenced by the mesolimbic dopamine system. It is hypothesized that a CSR generated by pairing a neutral stimulus with oral ethanol self-administration will influence both the initiation and maintenance oa an ethanol bout and the mesolimbic dopamine system will modulate the efficacy of both reinforcers. This hypothesis will be examined using operant techniques to asses (1) the ability of orally self- administered ethanol to establish a CSR, (2) the role of the CSR in the initiation and maintenance of ethanol consumption, and (3) the modulatory role of mesolimbic dopamine in ethanol and CSR reinforcement. Conditioned reinforcement will be assessed by the neutral stimuli's ability to maintain responding during operant extinction. Alterations in response rate ina the presence and absence of the CSR will be used to assess its role in initiation and maintenance of ethanol self-administration. Microinjection of amphetamine into the nucleus accumbens prior to an extinction session will be used to assess the role of mesolimbic dopamine in these processes. Examining the role of CSR in ethanol reinforcement will provide insight into their contribution to the maintenance of excessive ethanol consumption and release.