BEHAVIORAL AND NEUROPHYSIOLOGICAL CONTROL OF ALCOHOL

本研究旨在进一步了解心力衰竭的神经生理学。 乙醇消耗量。在之前的研究中，赫尔曼·萨姆森博士和辛迪博士 埃勒斯，申请人已经开始审查行为规则 酒精摄入与酒精相关的神经生理机制 曝光。目前的导师研究科学家发展奖将允许 继续培训神经生理记录技术和 合并两名申请者所需的乙醇消费动物模型 主要兴趣：酒精饮酒和大脑宏观生理学。该奖项将 允许申请者通过1)发展其科学专长 培训和监督合格的导师，2)职业发展 与各个酒精领域的杰出研究人员开展的活动 研究，以及3)完成旨在评估 调节酒精消耗的神经生理机制。这些研究 结合酒精消费模式(标准有限访问饮酒和 酒精剥夺后有限的饮酒机会)与艺术 电生理技术(脑电和ERPS)以进一步了解 动物模型中酒精摄入量的神经决定因素。建议数 研究利用酒精消耗的操纵来针对行为 以及调节酒精摄入量的重要环境因素，如 条件性刺激、“复发”和“渴望”。不同的操纵方式 产生适度或短暂的过量乙醇摄入，从而允许 功能性电活动同步变化的评估 发作期、维持期和复发阶段的多个脑区 饮酒行为。此外，乙醇摄入量将通过以下方式进行控制 检查发育期间酒精暴露的影响(新生儿和 青春期暴露)，以评估其与酒精摄入量和 神经生理活动。这些研究是第一批 系统评价大鼠脑内宏观神经生理活动 中皮质边缘环路参与乙醇摄取及其与多种因素的关系 酒精消费模式。

The present studies are aimed at further understanding the neurophysiology of ethanol consumption. In prior studies, with Dr. Herman Samson and Dr. Cindy Ehlers, the applicant has begun to examine the behavioral regulation of ethanol intake and the neurophysiological mechanisms associated with ethanol exposure. The present Mentored Research Scientist Development Award will allow for the continued training in the neurophysiological recording techniques and animal models of ethanol consumption necessary to merge the applicants two primary interests: ethanol drinking and brain macrophysiology. The award will allow for the development of the applicant's scientific expertise through 1) the training and supervision of a qualified mentor, 2) career development activities with distinguished researchers in various fields of alcohol research, and 3) the completion of studies designed to assess the neurophysiological mechanisms regulating ethanol consumption. These studies combine an alcohol consumption model (Standard Limited Access Drinking and Limited Access Drinking after Alcohol Deprivation) with state-of-the art electrophysiological techniques (EEG and ERPS) to further understand the neural determinants of alcohol consumption in an animal model. The proposed studies utilize manipulations of ethanol consumption that target behavioral and environmental factors important in regulating ethanol intake such as conditioned stimuli, "relapse", and "craving". The different manipulations generate moderate to transiently excessive ethanol intake allowing for the assessment of concurrent changes in the functional electrical activity of multiple brain regions during initiation, maintenance and "relapse" stages of drinking behavior. In addition, ethanol intake will be manipulated by examining the effects of ethanol exposure during development (neonatal and periadolescent exposure) to assess its relation to ethanol consumption and neurophysiological activity. These studies are among the first to systematically assess the macro-neurophysiological activity in the mesocorticolimbic circuit involved ethanol intake and its relation to various ethanol consumption paradigms.