BEHAVIORAL AND NEUROPHYSIOLOGICAL CONTROL OF ALCOHOL

目前的研究旨在进一步了解神经生理学 乙醇消费在之前的研究中，赫尔曼萨姆森博士和辛迪博士 Ehlers，申请人已经开始审查行为监管， 乙醇摄入量和与乙醇相关的神经生理机制 exposure.目前的指导研究科学家发展奖将允许 继续接受神经生理学记录技术的培训， 乙醇消耗的动物模型需要合并申请人的两个 主要兴趣：酒精饮料和大脑宏观生理学。该奖项将 允许申请人通过以下方式发展其科学专长：1） 培训和监督合格的导师，2）职业发展 与酒精各领域杰出研究人员的活动 研究，以及3）完成旨在评估 调节乙醇消耗的神经生理机制。这些研究 联合收割机结合酒精消费模型（标准限量饮酒和 酒精去除后的有限饮酒）与最先进的 电生理技术（EEG和ERPS）以进一步了解 在动物模型中酒精消耗的神经决定因素。拟议 研究利用乙醇消费的操纵，目标是行为 以及调节乙醇摄入量的重要环境因素， 条件刺激、“复发”和“渴望”。不同的操作 产生中度到短暂过量的乙醇摄入， 功能性电活动的并发变化的评估 多个脑区在启动，维持和“复发”阶段， 饮酒行为此外，乙醇摄入量将受到 研究乙醇暴露在发展过程中的影响（新生儿和 青少年期暴露），以评估其与乙醇消费的关系， 神经生理活动这些研究是第一批 系统地评估了大脑中的宏观神经生理活动， 中皮质边缘回路参与乙醇摄入及其与各种 乙醇消费模式。

The present studies are aimed at further understanding the neurophysiology of ethanol consumption. In prior studies, with Dr. Herman Samson and Dr. Cindy Ehlers, the applicant has begun to examine the behavioral regulation of ethanol intake and the neurophysiological mechanisms associated with ethanol exposure. The present Mentored Research Scientist Development Award will allow for the continued training in the neurophysiological recording techniques and animal models of ethanol consumption necessary to merge the applicants two primary interests: ethanol drinking and brain macrophysiology. The award will allow for the development of the applicant's scientific expertise through 1) the training and supervision of a qualified mentor, 2) career development activities with distinguished researchers in various fields of alcohol research, and 3) the completion of studies designed to assess the neurophysiological mechanisms regulating ethanol consumption. These studies combine an alcohol consumption model (Standard Limited Access Drinking and Limited Access Drinking after Alcohol Deprivation) with state-of-the art electrophysiological techniques (EEG and ERPS) to further understand the neural determinants of alcohol consumption in an animal model. The proposed studies utilize manipulations of ethanol consumption that target behavioral and environmental factors important in regulating ethanol intake such as conditioned stimuli, "relapse", and "craving". The different manipulations generate moderate to transiently excessive ethanol intake allowing for the assessment of concurrent changes in the functional electrical activity of multiple brain regions during initiation, maintenance and "relapse" stages of drinking behavior. In addition, ethanol intake will be manipulated by examining the effects of ethanol exposure during development (neonatal and periadolescent exposure) to assess its relation to ethanol consumption and neurophysiological activity. These studies are among the first to systematically assess the macro-neurophysiological activity in the mesocorticolimbic circuit involved ethanol intake and its relation to various ethanol consumption paradigms.