CLINICAL AND THERAPEUTIC STUDIES OF THE RHEUMATIC DISEASES

我们正在进行一系列的临床调查， 与系统性红斑狼疮相关的问题 发病机制，流行病学，治疗和共病的解决。 正在进行的治疗研究包括一项长期的随机试验， 皮质类固醇和免疫抑制药物治疗严重， 增生性狼疮性肾小球肾炎和核苷I/II期 类似物2-氯脱氧腺苷和DNASE在狼疮患者中相似 肾炎 目前正在进行研究，以评估与 骨质疏松症和血管血栓事件的发展。 与对狼疮发病机制感兴趣的科学家合作研究 在过去的一年中，包括细胞因子的影响， 自身免疫（D. Klinman），抗体与染色质结合， 肾小球基底膜胶原（J.B. Lefkowith），以及 Fc γ RIIa等位基因是非裔美国人肾炎的危险因素 （J.E.鲑鱼）。

We are conducting a series of clinical investigations involving patients with systemic lupus erythematosus in which questions related to disease pathogenesis, epidemiology, therapy and co-morbidities are addressed. Therapeutic studies in progress include a long-term, randomized trial of corticosteroids and immunosuppressive drugs in patients with severe, proliferative lupus glomeruonephritis and phase I/II of the nucleoside analog 2-chlorodeoxyadenosine and DNASE similarly in patients with lupus nephritis. Studies are underway to assess risk factors associated with the development of osteoporosis and vascular thrombotic events. Collaborative studies with scientists interested in lupus pathogenesis during the past year have included the influences of cytokines in autoimmunity (D. Klinman), antibody binding to chromatin adherent to the collagen of the glomerular basement membrane (J.B. Lefkowith), and FcgammaRIIa alleles as risk factors for nephritis in African-Americans (J.E. Salmon).