HIGH DOSE METHOTREXATE WITH LEUCOVORIN RESCUE IN RHEUMATOID ARTHRITIS

5例重症难治性类风湿患者 大剂量甲氨蝶呤静脉注射治疗关节炎 亚叶酸钙500 mg/m2，亚叶酸钙50 mg/m2。四道菜 化疗间隔超过2个月。在…的末尾 最后一个疗程，关节有50%或更多的改善 所有患者的肿胀和疼痛指数以及晨僵。 治疗后临床反应持续6-14周。高 剂量甲氨蝶呤-亚叶酸钙与显著的 外周血亮氨酸2、亮氨酸3细胞DR抗原表达降低 Leu-4淋巴细胞。

Five patients with severe, treatment refractory rheumatoid arthritis were treated with high dose intravenous methotrexate (500mg/m2) followed by leucovorin (50 mg/m2). Four courses of chemotherapy were given over a 2 month interval. At the end of the final course, there are a 50% or greater improvement in joint swelling and pain indices and morning stiffness in all patients. Clinical responses persisted for 6 to 14 weeks post therapy. High dose methotrexate-leucovorin was associated with a significant reduction in DR antigen expression on peripheral Leu 2, Leu 3 and Leu 4 lymphocytes.