CLINICAL AND THERAPEUTIC STUDIES OF THE RHEUMATIC DISEASES

我们进行了一系列涉及患者的临床调查 系统性红斑狼疮--一种慢性、复发和缓解型 以免疫介导的炎症为特征的疾病。海流 研究主要集中在#年狼疮性肾炎患者。 试图评估与治疗相关的实际问题 烷基化剂环磷酰胺，特别是研究新的 疾病管理的方法。一项可行性研究表明 门诊口服环磷酰胺团剂治疗是安全的 一种有效的减少环磷酰胺诱导的改进方案 恶心已经被研究过了。一种小鼠单抗的小型初步研究 抗CD5蓖麻毒素A链免疫结合物在6例慢性肝炎患者中的应用 有临床证据的外周T细胞数量减少 两例狼疮性肾炎患者病情改善。

We have conducted a series of clinical investigations involving patients with systemic lupus erythematosus - a chronic, relapsing and remitting disorder characterized by immune-mediated inflammation. The current studies have mainly focused on patients with lupus glomerulonephritis in an attempt to assess practical issues related to therapy with the alkylating agent cyclophosphamide and, in particular, to investigate new approaches to disease management. A feasibility study has demonstrated that outpatient therapy with bolus oral cyclophosphamide is safe and effective and an improved regimen for minimizing cyclophosphamide-induced nausea has been studied. A small pilot study of a murine monoclonal anti-CD5 ricin A chain immunoconjugate in 6 patients documented a chronic reduction in peripheral T cell populations with evidence of clinical improvement in two patients with lupus nephritis.