EFFECT OF STRENGTHENING EXERCISES ON LYMPHOCYTE SUBPOPULATION IN HEALTHY ADULTS

加强运动对健康成年人淋巴细胞亚群的影响

• 批准号: 2571479
• 负责人: J P SHAH
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2571479
• 关键词: clinical research; exercise; helper T lymphocyte; human subject; immunity; lymphocyte; muscle strength; natural killer cells; suppressor T lymphocyte

Ten healthy, sedentary males, ages 23 to 56, participated in a 6- week supervised strengthening program in which five subjects exercised and five did not. Peak torque (PT) and total work (TW), and the percentage and absolute numbers of CD4 T cells, CD8 T cells, and NK cells were measured before, during, and after exercise. PT and TW showed significant increases over time only when the two groups were combined. There were no significant changes in the percentages and absolute numbers of CD4 T cells, CD8 T cells, and NK cells. Pearson correlations between PT and TW were significant: t=.97, p=.001. NK cell distribution was negatively correlated with CD8 T cells: r=.56, P=.009. CD4 cell distribution was weakly correlated with PT (r=.45, P=.047) and with TW (r=.56, P=.01). The correlations between CD4 and PT, and CD4 and TW imply that there is a modest association between these measures and CD4 cell distribution. The study was completed in January 1996.

10名健康、久坐不动的男性，年龄在23到56岁之间，参加了一项6- 一周的监督强化计划，其中五个科目 五是锻炼，五是不锻炼。峰值扭矩（PT）和总功（TW）， 以及CD 4 T细胞，CD 8 T细胞， 分别于运动前、运动中、运动后测定NK细胞。PT 和TW随着时间的推移显示出显着增加，只有当两个 组合并。没有明显的变化， CD 4 T细胞、CD 8 T细胞和NK细胞的百分比和绝对数 细胞PT和TW之间的Pearson相关性显著： t=.97，p=.001。NK细胞分布与 CD 8 T细胞：r=.56，P=.009。CD 4细胞分布较弱 与PT（r= 0.45，P= 0.047）和TW（r= 0.56，P= 0.01）相关。的 CD_4与PT、CD_4与TW之间的相关性表明， 这些措施和CD 4细胞之间的适度关联 分布这项研究已于一九九六年一月完成。