EFFECT OF EXERCISE ON LYMPHOCYTE SUBPOPULATION IN HEALTHY ADULTS

运动对健康成年人淋巴细胞亚群的影响

• 批准号: 5201230
• 负责人: J P SHAH
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5201230
• 关键词: adult human (21+); exercise; female; helper T lymphocyte; human subject; immunity; lymphocyte; natural killer cells; suppressor T lymphocyte

The purpose of this project is to determine the effect of strengthening exercises on lymphocyte subpopulations (CD4 T cells, CD 8 T cells, Natural Killer Cells) in healthy adults. It is widely believed that regularly performed exercise helps improve resistance to infection. As a replicable and quantifiable stressor, the effect of exercise on immune function has interested numerous investigators. To our knowledge, this is the first study to look at the effects of strengthening exercises on changes in immune cell populations. Eight healthy, sedentary female subjects, ages 28-54, have completed the study. Four subjects exercised and 4 were control for each of two trials with different intensity and frequency of training. Peak torque and total work, and the percent and absolute numbers of CD4 T cells, CD8 T cells and NK cells were measured pre, during and post exercise. Upon comparing the direction and magnitude of changes in percent and absolute numbers of cells, there was no significant difference between the exercise groups and control groups in either trial 1 or trial 2. The intensity of exercise will be increased for the next group of subjects because no significant training effect was obtained. The next two groups will be men as per our protocol.

本项目的目的是确定加固效果 对淋巴细胞亚群（CD 4 T细胞、CD 8 T细胞、自然 在健康的成年人中。人们普遍认为， 进行锻炼有助于提高抵抗感染的能力。作为一个可复制的 和可量化的应激源，运动对免疫功能的影响， 引起了众多研究者的兴趣。据我们所知，这是第一个 研究加强锻炼对改变 免疫细胞群体。8名健康久坐女性受试者，年龄 28-54，已完成研究。4名受试者进行了锻炼， 控制两个试验中的每一个，具有不同的强度和频率， 训练峰值扭矩和总功，以及百分比和绝对数 CD 4 T细胞、CD 8 T细胞和NK细胞在术前、术中和术后均进行了检测。 锻炼后。在比较变化的方向和幅度时， 细胞百分率和绝对数无显著性差异 在试验1或试验2中， 2.下一组的运动强度会增加， 因为没有取得显著的训练效果。未来两 根据我们的协议，所有人都是男性