EFFECT OF EXERCISE ON LYMPHOCYTE SUBPOPULATION IN HEALTHY ADULTS

运动对健康成年人淋巴细胞亚群的影响

• 批准号: 3752306
• 负责人: J P SHAH
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3752306
• 关键词: T lymphocyte; aging; exercise; human subject; immunity; lymphocyte; natural killer cells

The purpose of this project is to determine the effect of strengthening exercises on lymphocyte subpopulations (CD 4 T cells, CD 8 T cells, Natural Killer Cells) in healthy adults. There is a decrease in immunocompetence with aging. Specifically, there is a decline in lymphocyte proliferation in response to antigen stimulation in older adults. This phenomenon in part, contributes to the increased susceptibility of the elderly to infection. It is widely believed that regularly performed exercise helps improve resistance to infection. As a replicable and quantifiable stressor, the effect of exercise on immune function has interested numerous investigators. Indeed, many studies have looked at the relationship between aerobic types of exercise and immune function. To our knowledge, this is the first study to look at the effects of strengthening exercises on immune function. Ten subjects have been recruited from the Clinical Center to participate in the first of four exercise groups. Baseline levels of lymphocytes and baseline strength of both quadriceps and hamstrings have been measured and recorded. The group has been divided into an exercise group and control group, based on ranked order of total strength. The exercise group will begin the exercise training shortly and this will continue twice a week for eight weeks. Three more groups will follow in identical fashion.

本项目的目的是确定加固效果 对淋巴细胞亚群（CD 4 T细胞，CD 8 T细胞， 自然杀伤细胞（NK）在健康成年人中 有所下降 免疫活性与衰老的关系 具体而言， 老年人淋巴细胞对抗原刺激的反应 成年人了 这一现象在一定程度上导致了 老年人对感染的易感性。 外界普遍认为 经常运动有助提高抵抗感染的能力。 作为 可复制和可量化的应激源，运动对免疫功能的影响， 功能引起了许多研究人员的兴趣。 事实上，许多研究 研究了有氧运动和免疫功能之间的关系， 功能 据我们所知，这是第一次研究 强化运动对免疫功能的影响。 10名受试者 从临床中心招募，参加第一次 四个锻炼组。 淋巴细胞基线水平和基线 股四头肌和腿筋的力量已经被测量， 记录。 该组被分为运动组和对照组 组，根据总实力的排名顺序。 演习小组将 我将开始短期内的运动训练，并将继续每周两次 八个星期。 另外三个小组将以同样的方式跟进。