CONSULTATION IN BIOSTATISTICAL METHODOLOGY AND CANCER CONTROL

生物统计方法学和癌症控制咨询

• 批准号: 2571514
• 负责人: C C BROWN
• 金额: --
• 依托单位: DIVISION OF CANCER PREVENTION AND CONTROL
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2571514
• 关键词: breast neoplasms; cancer information system; cancer prevention; cancer risk; chemoprevention; clinical research; colon neoplasms; colorectal neoplasms; data collection methodology /evaluation; dietary supplements; human data; information dissemination; longitudinal human study; neoplasm /cancer epidemiology; nutrition aspect of cancer; nutrition related tag; prostate neoplasms; retinoids; statistical service /center; statistics /biometry; tamoxifen

The purpose of this project is to provide independent consultation to researchers within the NCI on problems related to biostatistical methodology and cancer control. Current projects include: - in collaboration with the Cancer Prevention Studies Branch, the American Association of Retired Persons (AARP) Observational Cohort Study has entered its second year; during the past year, the mailed baseline food frequency questionnaire was completed and returned by over 600,000 AARP members; potential participants in a validation/calibration substudy were selected and enrolled; two 24-hour diet recalls were obtained by telephone for the 2,000 substudy subjects; the results are currently being entered into computer form and analysis will soon begin; this project will construct a cohort of AARP members to investigate the relationship between their current dietary intake and their future incidence of cancer of the breast, colon/rectum, and prostate. - in collaboration with the Cancer Prevention Studies Branch, we completed research projects on 1) dietary folate intake and colorectal cancer and 2) the effects of dietary fat and fiber intake on androgen and estrogen levels in men. - in collaboration with the Cancer Prevention Studies Branch and the Applied Research Branch, a newly developed food frequency questionnaire (FFQ) is being evaluated; participants are currently being enrolled in a study using a daily checklist of selected foods to evaluate the food frequency accuracies of a sample of questionnaire items; the responses to an RFP for estimating the new questionnaire's measurement errors of selected nutrients and comparing its error to that of two other commonly used FFQs were evaluated, a proposal was selected for award and negotiations are currently underway; robust regression methods to convert food frequencies into nutritional intakes based on the subject's age, gender and FFQ-reported portion size are being developed and evaluated. - in consultation with the Applied Research Branch, DCPC and the Office of Cancer Communications, evaluatating the accuracy of the Cancer Information System services to the general public is continuing. - in collaboration with the Epidemiology and Biostatistics Program of the DCEG, dietary data from a case control study of lung cancer in women are currently being examined. - in consultation to the Laboratory of Chemoprevention, DCEG, we analyzed results of a study on the tumor-suppressor activity of the transforming growth factor- (TGF-beta) and the results of an experiment of the anti-prostate tumor effect of combining raloxifene with either 9-cis-retinoic acid or 4-HPR. - in collaboration with the Prevention and Control Extramural Branch, the Section provides consultation on the analysis and evaluation of the 5 A Day Program -- NCI's campaign to increase fruit and vegetable consumption. - in collaboration with the Environmental Epidemiology Branch, DCEG, gender differences in cytochrome P4501A2 are being investigated in relation to differences in dietary intake.

该项目的目的是提供独立的 就问题向 NCI 内的研究人员进行咨询 与生物统计方法和癌症控制有关。 目前的项目包括： - 与癌症预防研究合作 美国退休人员协会 (AARP) 分会 观察队列研究已进入第二年； 在过去的一年里，邮寄基线食物频率 问卷已完成并回收超过60万份 美国退休人员协会会员；潜在参与者 选择并登记验证/校准子研究； 通过电话获得了两次 24 小时饮食回忆 2,000个子研究科目；目前结果正在 输入计算机形式并很快开始分析； 该项目将组建一批美国退休人员协会 (AARP) 成员 调查他们目前的饮食之间的关系 摄入量及其未来乳腺癌的发病率， 结肠/直肠和前列腺。 - 与癌症预防研究合作 分公司，我们完成了1）膳食叶酸的研究项目 摄入量与结直肠癌的关系以及 2) 饮食的影响 脂肪和纤维摄入量对雄激素和雌激素水平的影响 男人。 - 与癌症预防研究合作 新成立的分院和应用研究分院 食物频率问卷（FFQ）正在评估中； 参与者目前正在参加一项研究，使用 每日选定食物​​清单以评估食物 问卷项目样本的频率准确性； 对 RFP 的回复以估计新的 问卷所选营养素的测量误差 并将其误差与其他两种常用的误差进行比较 对 FFQ 进行了评估，选择了一项提案进行奖励并 目前谈判正在进行中； 稳健回归 将食物频率转化为营养的方法 根据受试者的年龄、性别和 FFQ 报告的摄入量 份量大小正在制定和评估中。 - 与 DCPC 应用研究部门协商 和癌症通讯办公室，评估 癌症信息系统服务的准确性 公众仍在继续。 - 与流行病学和生物统计学合作 DCEG 计划，来自病例对照研究的饮食数据 目前正在检查女性肺癌的发生率。 - 咨询化学预防实验室， DCEG，我们分析了一项研究结果 转化生长的肿瘤抑制活性 因子-（TGF-β）和实验结果 雷洛昔芬与雷洛昔芬联合应用的抗前列腺肿瘤作用 9-顺式视黄酸或4-HPR。 - 与预防和控制部门合作 校外分部，该科提供有关 每日 5 次计划的分析和评估——NCI 开展增加水果和蔬菜消费的运动。 - 与环境流行病学合作 细胞色素 P4501A2 的分支、DCEG、性别差异为 正在调查饮食差异 摄入量。