Phylogenetic methods for genome surveillance of microbial pathogens

微生物病原体基因组监测的系统发育方法

• 批准号: DE190100805
• 负责人: Dr Sebastian Duchene
• 金额: $ 26.87万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-04-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE190100805
• 关键词: Phylogenetic; methods; genome; surveillance; microbial

This project aims to develop phylogenetic approaches to harness the potential evolution of bacterial and virus pathogens data and to improve early detection of infectious outbreaks. Genome surveillance programs consist in routine sequencing of particular organisms to track their evolution over time. Such programs currently exist for important bacterial and virus pathogens. This project expects to develop computational methods to improve our understanding of pathogen outbreak emergence and infectious spread using genome data. This project will expand our knowledge base and research capability in the evolution and epidemiology of infectious agents, and aid in the prevention and control strategies of infectious disease benefiting the research priorities of food and health.

该项目旨在开发系统发育方法，以利用细菌和病毒病原体数据的潜在演变，并改善传染病爆发的早期检测。基因组监测计划包括对特定生物体进行常规测序，以跟踪它们随时间的演变。目前存在针对重要细菌和病毒病原体的此类程序。该项目期望开发计算方法，以提高我们对病原体爆发出现和使用基因组数据的感染传播的理解。该项目将扩大我们在传染性病原体的演变和流行病学方面的知识基础和研究能力，并帮助制定传染病的预防和控制战略，使食品和健康的研究重点受益。