Data-driven phylodynamics: molecular evolution to epidemiology

数据驱动的系统动力学：从分子进化到流行病学

• 批准号: FT220100629
• 负责人: Dr Sebastian Duchene
• 金额: $ 51.84万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT220100629
• 关键词: Data; driven; phylodynamics; molecular; evolution

This project aims to uncover how different environmental and ecological variables drive the emergence of pathogens with increased transmissibility or virulence, known as variants. This will be achieved through extensive analyses of virus genome data. This project expects to generate new knowledge in the field of pathogen evolution using novel data-driven statistical techniques for genomic analyses. Expected outcomes of this project are a new understanding of the circumstances under which pathogen variants emerge and a suite of statistical tools to exploit the vast genome data available. This should provide significant benefits by generating new knowledge with the potential to improve biosecurity, agriculture, and heath.

该项目旨在揭示不同的环境和生态变量如何驱动具有增加的传播性或毒力的病原体（称为变体）的出现。这将通过对病毒基因组数据的广泛分析来实现。 该项目预计将在病原体进化领域产生新的知识，使用新的数据驱动的统计技术进行基因组分析。 该项目的预期成果是对病原体变异出现的情况有了新的认识，并开发出一套统计工具来利用现有的大量基因组数据。 这将产生新的知识，有可能改善生物安全、农业和健康，从而带来巨大的好处。