PRIMITIVE POPULATIONS--CHILD DEVELOPMENT,BEHAVIOR,AND DISEASE PATTERNS

原始人群——儿童发育、行为和疾病模式

• 批准号: 2579501
• 负责人: D C GAJDUSEK
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2579501
• 关键词: aging; behavior; child (0-11); culture; developmental neurobiology; human subject; human tissue; interview; learning; nervous system disorder epidemiology; nutrition related tag

Studies of human biology of vanishing primitive societies focus on neurologic development and learning patterns in diverse cultural experiments in the human condition found in such isolated groups. Opportunistic investigation of problems phrased by man in isolation is the basis of approach from which most of our studies evolved: kuru-CJD GSS-FFI, HIV (AIDS), HTLV-I slow virus infections of the CNS, aging and Alzheimer's, VE, ALS/PD, mental disease, toxic neuropathies. Techniques of molecular genetics, biochemistry, immunology, virology, and field epidemiologic, clinical linguistic and behavioral studies in cultural isolates and genetic and/or geographically isolated primitive bands yield more easily interpretable data than in cosmopolitan societies. Data and specimens from expeditions to Micronesia, Melanesia, Polynesia, South America, Asia and Africa were valuable in recent HIV (AIDS), HTLV-I hantavirus, JCV of PML and herpes virus, CMV and EBV studies. Studies on nutrition, reproduction, fertility, age of puberty and aging, genetic distance and pleomorphisms, unusual and odd higher cortical functions in language learning, cognitive styles, computation (calculation without words or numbers) and culturally modified sexual behavior elucidate alternative forms of neurologic functioning for man which we cannot investigate once the natural cultural experiments in primitive human isolates are amalgamated into the cosmopolitan community of man. Foci of high incidence of kuru, ALS/PD, HTLV-I myelopathy, epilepsy, familial parkinsonism, Viliuisk encephalopathy, other CNS degenerations, hysterical disorders, schizophrenia, bipolar psychoses, neoplasms, goiter, cretinism, rheumatoid diseases, diabetes, asthma, chronic lung disease, malaria, filariasis, leprosy, cysticercosis, and other infections in these isolated groups have yielded widely significant discoveries. HFRS caused by hantaviruses in Asia, USSR, Europe and newly recognized hantaviruses in the U.S. are studied. Human evolution and adaptability to high altitude, various climes, variable food supply, mineral deficiencies, toxic exposures and responses to severe diseases or social psychologic stress are studied in appropriate populations. Thus, HTLV-1 and HIV retroviruses as causes of CNS diseases in man were first found and are best studied in isolated or socially segregated groups: high incidence TSP focus in Tuamaco, Colombia; drug-using mothers in Newark, New Jersey; epidemic neuropathy in Cuba. We now have a proto- Melanesian variant of HTLV-I in New Guinea and Solomon Islands, of an archaic origin, not associated with monkeys at least for millenia.

对正在消失的原始社会的人类生物学的研究重点是 不同文化中的神经系统发育和学习模式 在人类条件下的实验中发现了这样的孤立群体。 对孤立的人提出的问题进行机会主义的调查是 我们大多数研究的基础方法：kuru-CJD GSS-FFI、HIV（艾滋病）、HTLV-I 减缓中枢神经系统的病毒感染、衰老和 阿尔茨海默病、VE、ALS/PD、精神疾病、中毒性神经病。技巧 分子遗传学、生物化学、免疫学、病毒学和领域 文化领域的流行病学、临床语言学和行为研究 分离株和遗传和/或地理上分离的原始带产量 比国际化社会中的数据更容易解释。数据和 密克罗尼西亚、美拉尼西亚、波利尼西亚、南部探险队的标本 美洲、亚洲和非洲在最近的艾滋病毒（AIDS）、HTLV-I 中很有价值 汉坦病毒、PML 的 JCV 和疱疹病毒、CMV 和 EBV 研究。研究 营养、生殖、生育力、青春期和衰老年龄、遗传 距离和多态性，不寻常和奇怪的高级皮质功能 语言学习、认知风格、计算（无需计算） 文字或数字）和经过文化改造的性行为阐明 我们无法为人类提供神经功能的替代形式 调查一次原始人类的自然文化实验 孤立的人融入了人类的世界性社区。焦点 库鲁病、ALS/PD、HTLV-I 脊髓病、癫痫、家族性的高发病率 帕金森病、Viliuisk 脑病、其他中枢神经系统变性、 癔症、精神分裂症、躁郁症、肿瘤、 甲状腺肿、呆小病、类风湿病、糖尿病、哮喘、慢性肺病 疾病、疟疾、丝虫病、麻风病、囊尾蚴病等 这些孤立群体的感染产生了广泛的重大影响 发现。 HFRS 在亚洲、苏联、欧洲和新近由汉坦病毒引起 对美国公认的汉坦病毒进行了研究。人类进化和 适应高海拔、各种气候、变化的食物供应， 矿物质缺乏、有毒物质暴露和对严重疾病的反应 或社会心理压力在适当人群中进行研究。 因此，HTLV-1 和 HIV 逆转录病毒是导致人类中枢神经系统疾病的原因。 首先在孤立或社会隔离的环境中发现并进行最好的研究 群体： TSP 高发集中在哥伦比亚图阿马科；吸毒的母亲 新泽西州纽瓦克；古巴流行性神经病。我们现在有一个原型 新几内亚和所罗门群岛 HTLV-I 的美拉尼西亚变种 起源古老，至少几千年来与猴子无关。