PRIMITIVE POPULATIONS--CHILD DEVELOPMENT,BEHAVIOR,AND DISEASE PATTERNS

工作总结：患者的流行病学和临床评价 居住在西伯利亚亚库塔的维柳伊斯克脑病患者 在本报告所述期间进行了两次。 血液、脑脊液和 已经收集了尸检标本用于体内和体外分离 研究和组织病理学和免疫组织化学分析。 150例关岛ALS和PD患者DNA的分子遗传学研究 和200多个DNA标记来寻找易感基因。 随着Gajdusek博士的退休和Yanagihara博士的离开 夏威夷大学和Garruto博士到纽约州立大学，伯明翰新 约克，这个项目终止，1997年9月30日生效。

Summary of Work: Epidemiological and clinical evaluations of patients with Vilyuisk encephalopathy residing in Iakuta Siberia have been conducted on two occasions during this reporting period. Blood, CSF and autopsy specimens have been collected for in vivo and in vitro isolation studies and for histopathological and immunohistochemical analysis. Molecular genetics of Guamanian ALS and PD using DNA from 150 patients and more than 200 DNA markers in the search for a susceptibility gene. With the retirement of Dr. Gajdusek and the departure of Dr. Yanagihara to the University of Hawaii and Dr. Garruto to SUNY, Birmingham New York, this project is terminated, effective September 30, 1997.