PRIMITIVE POPULATIONS--CHILD DEVELOPMENT,BEHAVIOR,AND DISEASE PATTERNS

原始人群——儿童发育、行为和疾病模式

• 批准号: 6162977
• 负责人: D C GAJDUSEK
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6162977
• 关键词: Parkinson's disease; aging; amyotrophic lateral sclerosis; behavior; behavioral /social science research tag; blood chemistry; cerebrospinal fluid; child (0-11); culture; developmental neurobiology; genetic markers; hepatic coma /encephalopathy; histopathology; human genetic material tag; human subject; immunocytochemistry; interview; learning; molecular genetics; nervous system disorder epidemiology; nutrition related tag; postmortem

Summary of Work: Epidemiological and clinical evaluations of patients with Vilyuisk encephalopathy residing in Iakuta Siberia have been conducted on two occasions during this reporting period. Blood, CSF and autopsy specimens have been collected for in vivo and in vitro isolation studies and for histopathological and immunohistochemical analysis. Molecular genetics of Guamanian ALS and PD using DNA from 150 patients and more than 200 DNA markers in the search for a susceptibility gene. With the retirement of Dr. Gajdusek and the departure of Dr. Yanagihara to the University of Hawaii and Dr. Garruto to SUNY, Birmingham New York, this project is terminated, effective September 30, 1997.

工作总结：患者的流行病学和临床评估 居住在西伯利亚 Iakuta 的 Vilyuisk 脑病患者 本报告期内已进行过两次。 血液、脑脊液和 尸检标本已收集用于体内和体外分离 研究以及组织病理学和免疫组织化学分析。 使用 150 名患者的 DNA 进行关岛 ALS 和 PD 的分子遗传学研究 以及 200 多个 DNA 标记来寻找易感基因。 随着 Gajdusek 博士的退休和 Yanagihara 博士的离开 夏威夷大学和 Garruto 博士前往纽约州立大学伯明翰分校 约克，该项目已终止，自 1997 年 9 月 30 日起生效。