FORCE-FIELD CONTROL IN SPINAL REFLEXES

脊髓反射中的力场控制

• 批准号: 2655508
• 负责人: SIMON F GISZTER
• 金额: $ 8.5万
• 依托单位: ALLEGHENY UNIVERSITY OF HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-04-01 至 1998-11-10
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2655508
• 关键词: Rana; biomechanics; computational neuroscience; electromyography; neural information processing; neuromuscular function; neurophysiology; spinal cord mapping; spinal reflex

The discovery of structural and functional elements of motor behavior is one of the key issues in motor control. It is very likely that he kinds of units available in the spinal cord may constrain athe types and organization of descending controls, intermediate representations and sensorimotor transformations. Recently a new type of unit has been suggested, based on combined physiological and biomechanical data. This unit has been called a 'force- field primitive'. A force-field is a function that maps the forces generated ina the limb to the limb's configuration. The relationship between force-field primitives and other spinal mechanisms is not well understood. Primitives could represent general purpose promotor elements: the site of convergence of signals from descending, pattern generator and coordinating systems.. Alternatively, they could be elements associated exclusively with spina pattern generators. The types of force-field primitives corresponded closely to force-fields that could be measured during wiping, burning and flexion behaviors elicited in spinal frogs. It is thus clearly important to understand how force-field primitives are related to these reflex behaviors. To begin to relate force-field primitive descriptions to spinal pattern generators we propose the following; (1) We will record the kinematics, and electromyographic activity (EMG) of reflex behaviors and using accurate dynamic models we will relate these to the static force-field measurements and their EMGs recorded from tahe same behaviors. The reflex behaviors examined will be wiping, flexion withdrawal and aversive turning movements. (2) To examine interlimb coordination. (3) To address control and modulation of reflexes by descending systems, we will examine athe effects of bulbospinal control of afferents on the force-field structures, the EMGs and the kinematics in the wiping, flexion and turning behaviors. (4) Identified pathways associated with the turn and strike will be stimulated in reduced preparations to examine how these interact with the spinal reflex behaviors. The notion that a small number of 'primitives' may form a large part of the support of spinal behaviors, and, perhaps, descending control, is interesting for the following two reasons; First, it offers hope of a simple experimental understanding of spinal cored function. Second, it suggests that functional recovery from spinal injury may be possible in the future with only limited, but targeted, neural growth and connectivity. The experiments proposed will provide two critical sets of data to test this scheme of the organization of motor behavior; (1) a detailed understanding of the specific roles and organization of the force-field primitives in the known context of spinal behaviors, and (2) a description of how the force-field primitives in the known context of spinal behaviors, and (2) a description of how the force-field primitives used in spinal behaviors interact with de descending control.

运动行为的结构和功能要素的发现， 电机控制的关键问题之一。很有可能他 脊髓中可用的单元可以限制脊髓类型， 组织降序控件、中间表示和 感觉运动转换 最近有人提出一种新型的装置， 生理和生物力学数据。 这支部队被称为“部队- 场连续性'。 力场是一种映射力的函数 与肢体的形状相匹配。 的关系 力场基元和其他脊椎机制之间的联系 明白 基元可以表示通用启动子元素： 来自下行信号、模式发生器和 协调系统 或者，它们可以是与 专门用脊椎模式发生器 力场类型 基元与可以测量的力场密切相关 在擦拭，燃烧和弯曲行为引起的脊髓青蛙。 它 对于理解力场基元是如何 与这些反射行为有关。 要开始将力场基元描述与脊柱模式相关联， 我们提出以下的生成器;（1）我们将记录运动学， 和肌电图活动（EMG）的反射行为和使用准确的 动态模型，我们将这些静态力场测量 并记录了他们相同行为的肌电图。 反射行为 将检查擦拭、屈曲撤回和厌恶转动运动。 (2)检查肢体间的协调性。 (3)为了解决控制和 下行系统对反射的调制，我们将研究反射效应 球脊髓控制传入的力场结构， 以及在擦拭、弯曲和转动行为中的运动学。 （四） 与转弯和打击相关的识别路径将被刺激 在减少准备，以检查这些如何与脊髓相互作用， 反射行为 少数“原语”可能构成 脊髓行为的支持，也许，下行控制， 有趣的原因有以下两个;第一，它提供了一个 对脊髓核心功能的简单实验理解。 二是 表明脊髓损伤的功能恢复可能在 未来，只有有限的，但有针对性的，神经生长和连接。 所提出的实验将提供两组关键数据进行测试 该运动行为的组织方案;（1）详细的 理解力场的具体作用和组织 在脊椎行为的已知上下文中的基元，以及（2）描述 在已知的脊椎行为背景下，力场基元是如何， 以及（2）描述了如何在脊柱中使用力场原语 行为与递减控制相互作用。