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ALCOHOL INDUCED BEHAVIORAL TERATOGENESIS

酒精诱发的行为致畸

基本信息

批准号：
2769124
负责人：
EDWARD P RILEY
金额：
$ 24.79万
依托单位：
SAN DIEGO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1988
资助国家：
美国
起止时间：
1988-09-01 至 2000-08-31
项目状态：
已结题

项目摘要

Although a considerable amount of data has been published regarding the morphological and behavioral effects associated with prenatal alcohol exposure, very little information is known regarding the underlying mechanisms for these effects. Recently, alcohol's interaction with the prostaglandins has been implicated as one possible mechanism for some of the consequences associated with alcohol exposure in utero. Support for this hypothesis stems from studies showing that pretreatment with the prostaglandin synthetase inhibitors, aspirin and indomethacin, prior to alcohol exposure reduces fetal hypoplasia and the incidence of fetal death and malformations in mice. In this proposal, we plan to look at the role of prostaglandins in some of the behavioral and physiological effects that are found following prenatal alcohol exposure. In the first set of experiments, we will examine the effects of aspirin pretreatment will ameliorate some of the effects associated with prenatal alcohol exposure. In the first set of experiments, we will examine the effects of aspirin pretreatment will ameliorate some of the effects associated with prenatal alcohol exposure. In the first set of experiments, we will examine the effects of aspirin pretreatment and acute and chronic alcohol exposure on fetal movement, since alcohol exposure has been shown to result in a suppression of fetal movement. Also, reduced fetal movement has been suggested as one possible cause for some of alcohol's morphological effects. In the second series of experiments, we will examine the effects of aspirin pretreatment on sexually dimorphic behaviors and neuroanatomical structures that have been shown to be sensitive to prenatal alcohol exposure. The arachidonic acid cascade, which results in the production of prostaglandins, has been implicated in some of the effects of testosterone during fetal development and thus, may play a role in some of the alcohol-related changes in sexually dimorphic behaviors that have been reported. In the third series of experiments, the effects of aspirin pretreatment on a number of behaviors that are known to be sensitive to prenatal alcohol exposure will be examined to determine if this pretreatment can ameliorate some of the behavioral dysfunctions that are typically associated with prenatal alcohol exposure.

尽管已经公布了相当数量的关于产前饮酒对形态和行为的影响暴露，关于潜在的信息知之甚少产生这些效应的机制。最近，酒精与人体的互动前列腺素被认为是某些疾病的可能机制之一与子宫内酒精暴露相关的后果。支持这一假说源于研究表明，用前列腺素合成酶抑制剂，阿司匹林和消炎痛酒精暴露可降低胎儿发育不全和胎儿高血压的发生率小鼠的死亡和畸形。在本提案中，我们计划查看前列腺素在某些行为和生理方面的作用在产前酒精暴露后发现的影响。在第一个一组实验，我们将检查阿司匹林预处理的效果将会改善一些与产前酒精有关的影响曝光。在第一组实验中，我们将检查阿司匹林的预处理将改善与产前酒精暴露。在第一组实验中，我们将检测阿司匹林预处理和急、慢性酒精的影响对胎儿运动的暴露，因为酒精暴露已被证明会导致胎儿运动受阻。此外，胎儿运动减少已经被认为是一些酒精中毒的可能原因之一形态效应。在第二系列实验中，我们将检测阿司匹林预处理对性二形症的影响已经证明的行为和神经解剖结构对产前酒精暴露敏感。花生四烯酸级联反应，导致前列腺素的产生，已经牵涉到睾丸激素在胎儿发育过程中的一些作用，因此，可能在一些与酒精有关的性行为改变中发挥作用已经报道的二态行为。在第三个系列中实验，阿司匹林预处理对一些行为的影响已知对产前酒精暴露敏感的人将是检查以确定这种预处理是否可以改善一些通常与产前有关的行为障碍酒精暴露。