Brain Maturation in Adults with FASD

患有 FASD 的成人的大脑成熟度

• 批准号: 10442629
• 负责人: EDWARD P RILEY
• 金额: $ 33.7万
• 依托单位: SAN DIEGO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10442629
• 关键词: Address; Adolescence; Adolescent; Adult; Affect; Age; Age-Years; Aging; Alcohols; Anatomy; Animal Model; Anisotropy; Attention deficit hyperactivity disorder; Behavior; Behavioral; Brain; Brain scan; Cerebral cortex; Characteristics; Child; Classification; Clinical Research; Cognition; Cognitive; Data; Demographic Factors; Development; Diffuse; Diffusion; Diffusion Magnetic Resonance Imaging; Disease; Down Syndrome; Empirical Research; Entropy; Evaluation; Face; Family; Fetal Alcohol Exposure; Fetal Alcohol Spectrum Disorder; Fetal Development; Fetal alcohol effects; Follow-Up Studies; Goals; Growth; Human; Image; Impaired cognition; Individual; Knowledge; Life; MRI Scans; Magnetic Resonance Imaging; Methods; Myelin; Neurodevelopmental Disorder; Neuropsychological Tests; Outcome; Parietal; Participant; Pattern; Phase; Population; Protocols documentation; Public Health; Publishing; Quality of life; Recording of previous events; Registries; Reporting; Research; Rest; Sampling; Scanning; Seeds; Signal Transduction; Structure; System; Techniques; Teenagers; Testing; Time; Universities; Washington; Work; age group; age related; alcohol exposure; base; behavior test; cerebral atrophy; connectome; data modeling; developmental disease; disorder control; embryo/fetus; emerging adult; fetal; functional MRI scan; improved; in utero; insight; myelination; neurodevelopment; recruit; signal processing; white matter; young adult

Project Summary Exposure to alcohol in utero can have devastating effects on the developing fetus, including growth deficits, cognitive and behavioral anomalies, alterations in brain, and distinct facial characteristics; collectively these are referred to as fetal alcohol spectrum disorders (FASD). While research over the last 40 years has characterized these alterations and provided numerous potential mechanisms for the effects of prenatal alcohol exposure (PAE), very little data exists on long-term consequences as the majority of clinical research has focused on children and adolescents. Many of the consequences of PAE are thought to be lifelong, yet data on individuals past young adulthood are rare, despite animal model data suggesting long-term consequences and altered trajectories of behavioral development. The goal of this application is to address this significant shortfall in our knowledge by evaluating the protracted effects of prenatal alcohol exposure on the brain. Previous large studies from Seattle, WA developed well-characterized research samples of individuals with a classification of having an FASD who are now adults between 30 and 60 years of age. These individuals are currently being recruited into a registry of research participants. Over 150 of these individuals have had previous structural MRI scans conducted while in their teens and twenties. A subset of subjects and matched controls (N=90) will be recruited to have another MRI session in which structural, DTI, and connectivity assessments will be conducted. Comparisons between these and earlier scans will provide insight into the changes in overall brain structure, white matter integrity, and function with age in subjects with alcohol exposure histories. We postulate that brain maturation following PAE follows an altered trajectory relative to normal developing controls. This work will begin to examine a major gap in our knowledge about the impact of PAE by addressing for the first time the longitudinal changes in brain during the adult period, and identify gaps in knowledge regarding FASD in adulthood.

项目摘要 子宫内的酒精暴露会对发育中的胎儿产生毁灭性影响，包括生长不足， 认知和行为异常，大脑的改变以及不同的面部特征；这些都是这些 称为胎儿酒精谱系障碍（FASD）。虽然过去40年中的研究有 表征了这些改变，并为产前的影响提供了许多潜在的机制 酒精暴露（PAE），对于大多数临床研究，关于长期后果的数据很少 专注于儿童和青少年。 PAE的许多后果被认为是终生的 尽管动物模型的数据表明长期 后果和行为发展的轨迹改变。此应用的目的是解决 通过评估产前酒精暴露对产前酒精的持久作用对我们知识的显着不足 大脑。西澳西雅图以前的大型研究开发了良好的研究样本 患有FASD分类的人现在已经30至60岁。这些 目前正在将个人招募到研究参与者的注册表中。超过150个人 在十几岁和二十多岁的时候进行了以前进行的结构性MRI扫描。主题的子集 匹配的控件（n = 90）将被招募，以进行另一个MRI会话，其中结构，DTI和 连通性评估将进行。这些和较早扫描之间的比较将提供洞察力 饮酒受试者的整体大脑结构，白质完整性和随着年龄的功能的变化 暴露历史。我们假设PAE之后的大脑成熟遵循相对于 正常发育控制。这项工作将开始研究我们对有关影响的主要差距 PAE首次解决成人时期大脑的纵向变化，并确定差距 关于成年后FASD的知识。