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EPIDEMIOLOGY OF A D IN WOMEN--RISK AND IMPACT

女性 D 的流行病学——风险和影响

基本信息

批准号：
2732546
负责人：
LIESI E HEBERT
金额：
$ 10.59万
依托单位：
RUSH UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
1994
资助国家：
美国
起止时间：
1994-09-15 至 1999-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2732546
关键词：
Alzheimer's disease aging caregivers community disease /disorder proneness /risk extended care facility female functional ability gender difference health care service utilization human data human mortality institutional care facility prognosis statistics /biometry women's health

项目摘要

This is a revision of an application (1 R29 AG11862, "Epidemiology of Alzheimer's Disease in Women: Risk and Impact") which was not funded. Alzheimer's disease poses a large and growing public health problem for the U.S. and other developed countries. Because occurrence of the disease is very strongly related to age and because women live substantially longer than men, many more women are affected than are men. Gender differences both in risk of this disease and its consequences have received relatively little formal attention in epidemiologic studies, however. The proposed research will compare occurrence rates and disease consequences in women and men and provide projections of the growth in the numbers of affected women and men in the U.S. population. Existing data sets to which the investigators have full access will be used for these analyses. The hypothesis that the age-specific incidence and prevalence of Alzheimer's disease are higher among women than men will be tested in data from a defined community population. Possible gender differences in several important consequences of the disease will be examined: Hypotheses that the rate of decline in physical function is larger among women with Alzheimer's disease than men but that mortality is lower among women with the disease will each be tested in three different settings (community, institutional long-term care, non-institutional long-term care). The hypothesis that rates of aggressive behaviors are lower among women with Alzheimer's disease than among men will be examined in two of these settings (community, institutional long-term care). Use of medical services by persons with Alzheimer's disease will be examined in data from a defined community with the hypotheses that women with Alzheimer's disease are more likely to use acute care hospital services than men controlling for level of disease and other risk factors and also more likely to enter institutional long-term care. Finally, the growth of Alzheimer's disease among women in the U.S. population in the future will be examined, using a range of demographic projects. Women comprise the largest segment of all persons over age 65 and of the oldest old, and the size of these groups is growing rapidly. Accurate description of differences in risk and disease consequences is an essential first step in identifying both resource needs and potential avenues for intervention.

这是应用程序(1 R29 AG11862)的修订版妇女阿尔茨海默氏症：风险和影响“)，没有得到资助。阿尔茨海默病是一个巨大的、日益严重的公共卫生问题美国和其他发达国家。因为疾病的发生与年龄有很强的相关性，因为女性活得很长受影响的女性比男性多得多，时间比男性长得多。性别这种疾病的风险及其后果的差异在流行病学研究中受到的正式关注相对较少，然而。这项拟议的研究将比较发病率和疾病对女性和男性的影响，并提供对美国人口中受影响的女性和男性人数。现有数据调查人员拥有完全访问权限的集合将用于这些分析。假设特定年龄段的发病率和流行率将在数据中测试阿尔茨海默氏症在女性中的发病率高于男性从一个确定的社区人口中。可能存在的性别差异我们将研究这种疾病的几个重要后果：假设身体机能下降的速度在患有阿尔茨海默氏症患者的死亡率低于男性，但患有该疾病将分别在三个不同的环境中进行测试(社区、机构长期护理、非机构长期护理)。这个假设女性的攻击性行为发生率较低阿尔茨海默氏症在男性中将在其中两项中进行检查环境(社区、机构长期护理)。医疗服务的使用阿尔茨海默病患者的服务将在以下数据中进行检查一个明确的社区，假设患有阿尔茨海默氏症的女性疾病患者比男性更倾向于使用急诊医院服务控制疾病水平和其他风险因素，以及更多有可能进入机构长期护理。最后，中国的增长阿尔茨海默氏症在未来美国人口中的女性人数将使用一系列人口统计项目进行审查。女性构成了 65岁以上的所有人和最年长的老年人中最大的一部分，以及这些群体的规模正在迅速增长。准确描述风险和疾病后果的差异是关键的第一步确定资源需求和干预的潜在途径。