METALWORKING FLUIDS--PANCREATIC AND LIVER CANCER RISK

描述：（改编自研究者摘要） 汽车/汽车工人联合会（GM/UAW）的46，000名汽车工人是 这是迄今为止对接触金属加工液（MWF）的工人进行的最大规模的研究。 后续行动最近延长到1994年， 死亡人数。 已经进行了广泛的接触评估。 先前在该队列中研究了胰腺癌，发现其 与合成金属加工液密切相关， 研磨操作，OR = 3.0，95%CI：1.2-7.5。 合成液体是由 潜在的公共卫生问题，因为它们的使用正在扩大。 但在 先前的分析、潜伏期和累积暴露是有限的， 合成流体直到20世纪70年代初才得到广泛使用。 又一个十年的随访，胰腺癌的数量翻了一番 例，以及增加的累积暴露于合成流体中， 队列。 胰腺和胰腺癌的标准化死亡率（SMR） 从最初的死亡率研究开始， （1940-1984年）。 胰腺癌的风险增加也见于 黑人和女性是最近雇用的两个工人群体。 将对胰腺癌和胰腺癌进行单独的巢式病例对照研究。 肝胆癌 将联系登记中心，以核实 两种癌症的死亡率。 将拟合条件logistic回归模型 来估计暴露反应关系。 这两种癌症都被认为是 同样的建议有两个原因：器官共享一个紧密的解剖学和 生理关系，职业健康文献表明， 相关行业的类似风险。

DESCRIPTION: (Adapted from Investigator's Abstract) The General Motors/United Auto Workers (GM/UAW) cohort of 46,000 autoworkers is the largest study to date of workers exposed to metalworking fluids (MWFs). Follow-up has recently been extended through 1994, with a 50% increase in the number of deaths. An extensive exposure assessment has been conducted. Pancreatic cancer was previously investigated in this cohort and found it to be significantly associated with synthetic metalworking fluids used in grinding operations, OR = 3.0, 95% CI: 1.2-7.5. Synthetic fluids are of potential public health concern because their use is expanding. However, in the previous analysis, latency and cumulative exposures were limited because synthetics fluids did not come into widespread use until the early 1970's. Another ten years of follow-up has doubled the number of pancreatic cancer cases, as well as increased cumulative exposure to synthetic fluid in the cohort. Standardized mortality ratios (SMRs) for both pancreatic and hepatobiliary cancer have increased from the initial mortality study (1940-1984). The elevated risk for pancreatic cancer was also seen in blacks and females, the two most recently hired subgroups of workers. Separate nested case-control studies will be conducted for pancreatic and hepatobiliary cancer. Registries will be contacted to verify the cause of death for both cancers. Conditional logistic regression models will be fit to estimate exposure response relationships. Both cancers are considered in the same proposal for two reasons: the organs share a close anatomic and physiologic relationship, and the occupational health literature suggests similar risks in related industries.