METALWORKING FLUIDS--PANCREATIC AND LIVER CANCER RISK

金属加工液——胰腺癌和肝癌风险

• 批准号: 2760458
• 负责人: Ellen Aura Eisen
• 金额: $ 3.58万
• 依托单位: UNIVERSITY OF MASSACHUSETTS LOWELL
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2000-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2760458
• 关键词: cancer risk; clinical research; fluid; human mortality; human subject; liver neoplasms; metals; neoplasm /cancer epidemiology; occupational disease /disorder; occupational hazard; occupational health /safety; pancreas neoplasms

DESCRIPTION: (Adapted from Investigator's Abstract) The General Motors/United Auto Workers (GM/UAW) cohort of 46,000 autoworkers is the largest study to date of workers exposed to metalworking fluids (MWFs). Follow-up has recently been extended through 1994, with a 50% increase in the number of deaths. An extensive exposure assessment has been conducted. Pancreatic cancer was previously investigated in this cohort and found it to be significantly associated with synthetic metalworking fluids used in grinding operations, OR = 3.0, 95% CI: 1.2-7.5. Synthetic fluids are of potential public health concern because their use is expanding. However, in the previous analysis, latency and cumulative exposures were limited because synthetics fluids did not come into widespread use until the early 1970's. Another ten years of follow-up has doubled the number of pancreatic cancer cases, as well as increased cumulative exposure to synthetic fluid in the cohort. Standardized mortality ratios (SMRs) for both pancreatic and hepatobiliary cancer have increased from the initial mortality study (1940-1984). The elevated risk for pancreatic cancer was also seen in blacks and females, the two most recently hired subgroups of workers. Separate nested case-control studies will be conducted for pancreatic and hepatobiliary cancer. Registries will be contacted to verify the cause of death for both cancers. Conditional logistic regression models will be fit to estimate exposure response relationships. Both cancers are considered in the same proposal for two reasons: the organs share a close anatomic and physiologic relationship, and the occupational health literature suggests similar risks in related industries.

描述：（改编自研究者摘要）一般 汽车/美国汽车工人联合会 (GM/UAW) 的 46,000 名汽车工人群体是 迄今为止最大规模的针对接触金属加工液 (MWF) 的工人的研究。 随访最近延长至 1994 年，增加了 50% 死亡人数。 已经进行了广泛的暴露评估。 之前在该队列中对胰腺癌进行了研究，发现它 与合成金属加工液使用密切相关 研磨操作，OR = 3.0，95% CI：1.2-7.5。 合成液有 潜在的公共卫生问题，因为它们的使用正在扩大。 然而，在 之前的分析，延迟和累积暴露是有限的，因为 直到 20 世纪 70 年代初，合成液才得到广泛使用。 再追踪十年胰腺癌数量增加一倍 病例，以及累积接触合成液体的增加 队列。 胰腺癌和胰腺癌的标准化死亡率 (SMR) 肝胆癌的死亡率较最初的研究有所增加 （1940-1984）。 胰腺癌的风险升高也出现在 黑人和女性是最近雇用的两个工人群体。 将针对胰腺和胰腺进行单独的巢式病例对照研究 肝胆癌。 将联系注册处以核实原因 两种癌症均导致死亡。 条件逻辑回归模型将适合 估计暴露反应关系。 这两种癌症都被认为是 相同的建议有两个原因：这些器官具有相似的解剖结构，并且 生理关系，职业健康文献表明 相关行业存在类似风险。