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Prostate Cancer Morbidity and Metal Working Fluids

前列腺癌发病率与金属加工液

基本信息

批准号：
6667201
负责人：
Ellen Aura Eisen
金额：
$ 7.65万
依托单位：
UNIVERSITY OF MASSACHUSETTS LOWELL
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-09-30 至 2005-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6667201
关键词：
clinical research disease /disorder proneness /risk environment related neoplasm /cancer epidemiology hazardous substances hormones human data human morbidity human mortality male metal working fluid occupational hazard occupational health /safety prostate neoplasms

项目摘要

DESCRIPTION (provided by applicant): We are requesting funds to analyze data recently collected for a nested case-control study of prostate cancer incidence and exposure to metal working fluids (MWF). This proposed research will follow up preliminary data suggesting an association between prostate cancer mortality and MWF in a cohort study of automobile manufacturing workers with extensive quantitative information on exposure to straight, soluble and synthetic MWF. We have identified incident cases in the cohort through the state cancer registries and are proposing to analyze the case-control data in order to examine the hypothesis that oil or chemical components of these fluids may interfere with hormonal activity of the prostate, disrupt its normal function and contribute to the development of prostate cancer. We propose to use both parametric and nonparametric statistical models to examine the exposure-response relationships. Smoothing techniques based on penalized splines will be used in the nonparametric models to relax the assumption of linearity between exposure and risk. Exposure will be based on two different sets of exposure time windows. Exposure will be cumulated in consecutive windows defined by (1) periods of hormonal changes during a man's life (puberty to 35, 35-50 and > 50 years of age), and (2) suspected latency periods for prostate cancer, (10, 20, and 30 years prior to age at diagnosis). We will explore the healthy worker survivor effect by comparing three methods for reducing the bias, lagging cumulative exposure for 5 years to exclude recent exposures incurred by those who remained on the job, adjusting for employment status at the age of diagnosis, and controlling for time since hire as potential confounder. Because the cohort is 16% African-American, we will also examine race as a risk factor in prostate cancer incidence and survival.

描述(由申请人提供)：我们正在申请资金来分析最近为前列腺癌发病率和接触金属加工液(MWF)的嵌套病例对照研究收集的数据。这项拟议的研究将跟进初步数据，该数据表明，在汽车制造工人中进行的一项队列研究中，前列腺癌死亡率与MWF之间存在关联，该队列研究包含有关暴露于直链、可溶和合成MWF的大量定量信息。我们已经通过州癌症登记确定了队列中的事件病例，并提议分析病例对照数据，以检验这些液体中的油或化学成分可能干扰前列腺的激素活动、扰乱其正常功能并导致前列腺癌发展的假设。我们建议使用参数和非参数统计模型来检验暴露-反应关系。基于惩罚样条法的平滑技术将在非参数模型中使用，以放松风险暴露与风险之间的线性假设。曝光将基于两组不同的曝光时间窗口。根据(1)男性一生中荷尔蒙变化的时期(青春期至35岁、35-50岁和50岁)，以及(2)前列腺癌的可疑潜伏期(确诊年龄前10年、20年和30年)，将累积暴露在连续的窗口中。我们将通过比较三种方法来探讨健康工人的生存效应：减少偏差、滞后5年的累积暴露以排除那些仍在工作的人最近发生的暴露、在诊断年龄调整就业状况以及控制受雇时间作为潜在的混杂因素。由于队列中16%是非裔美国人，我们还将研究种族作为前列腺癌发病率和存活率的风险因素。