GORDON CONFERENCE ON INTERMEDIATE FILAMENTS

戈登中间长丝会议

• 批准号: 2721356
• 负责人: JEAN-PIERRE JULIEN
• 金额: $ 0.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-20 至 1999-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2721356
• 关键词: cell membrane; intermediate filaments; keratin; meeting /conference /symposium; nervous system disorder; neural degeneration; neurofilament; phosphorylation; protein structure; protein structure function; protein transport; skin disorder; travel

The purpose of this proposal is to generate funds to support travel, registration and subsistence for participants in the 5th Gordon Research Conference on Intermediate Filaments, which will be held July 12-17, 1998 at the Holderness School, Plymouth, New Hampshire, U.S.A. Intermediate filaments (IFs) are prominent components of the cytoskeleton of higher eukaryotic cells. In vertebrates there are over 40 different IF subunit protein (IFP) genes, which are expressed in a cell-type specific manner. It is now clear that defects in IF organization are the direct cause of, and may contribute to a wide range of human diseases including neurodegenerative diseases, myopathies, cardiomyopathies, and diseases of the epidermis and liver. This realization has re-energized the community of scientists studying IFs. The Gordon Research Conference on Intermediate Filaments is the only regular meeting devoted to IF biology and it brings together an international cast of participants, including basic scientists and clinicians, well established figures and younger scientists with the goal of facilitating an exchange of the latest ideas, observations and reagents. The major themes of the 1998 IF Gordon Conference will be: 1) Evolution and structure of IFs, 2)Assembly, transport and phosphorylation of neuronal IFs, 3) Regulation and functions of the major IFPs, 4) Keratins in skin disorders and in cancer, 5) Neurofilaments in neurodegenerative diseases, 6) Interactions of IFs with other cellular components and with the plasma membrane.

本提案的目的是筹集资金， 第五届戈登研究会与会者的登记和生活费 中间纤维会议将于7月12日至17日举行， 1998年在美国新罕布什尔州普利茅斯的霍勒学校学习 中间纤维（IF）是纤维的主要组成部分。 高等真核细胞的细胞骨架。 在脊椎动物中， 40种不同的IF亚基蛋白（IFP）基因，它们在一个 细胞类型特异性方式。 现在很清楚，如果 组织是直接原因，并可能有助于广泛的 包括神经变性疾病，肌病， 心肌病以及表皮和肝脏疾病。 这 这一认识重新激发了研究IF的科学家群体的活力。 戈登中间纤维研究会议是唯一的 定期会议专门讨论IF生物学，它汇集了一个 包括基础科学家在内的国际参与者， 临床医生、知名人士和年轻的科学家， 目标是促进交流最新的想法、意见和建议， 试剂 1998年联合会戈登会议的主要主题是： 1)国际单项体育联合会的演变和结构，2）组装、运输和 神经元IFs的磷酸化，3）神经元IFs的调节和功能， 主要IFPs，4）皮肤病和癌症中的角蛋白，5） 神经退行性疾病中的神经丝，6）IF的相互作用 与其他细胞成分和质膜结合。