HIV-1 PG120 V3 LOOP TARGETING--NOVEL POTENTIAL INHIBITOR
HIV-1 PG120 V3 LOOP TARGETING--NOVEL POTENTIAL INHIBITOR
批准号:
2751045
负责人:
A ROBERT ROBERT NEURATH
金额:
$2.0万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1996
资助国家:
美国
项目状态:
已结题
起止时间:
1996-08-01 至 1999-07-31
中文摘要
描述:母补助金(CA43315-09)涉及的合成
英文摘要
DESCRIPTION: The parent grant (CA43315-09) deals with the synthesis of
antiviral compounds targeted to the V3 loop, the definition of their
structure-function relationships, assessment of their antiviral activity
against primary HIV-1 isolates, and the design of compounds with reactive
groups leading to irreversible binding to gp120/41. The proposed FIRCA
aims are the synthesis of (a) new porphyrin derivatives, (b)
phosphorothioate cytosine oligonucleotides with various pentofuranosyl
configurations and phosphonate cytosine oligonucleotides with
hydrophobic functional groups inserted in the vicinity of the
phosphonate moieties, and (c) conjugates of the porphyrin derivatives and
oligonucleotides. The in vitro testing of the synthesized molecules for
anti-HIV effect and their binding to gp120 and the V3 loop will be done
as part of the parent grant. The foreign collaborator (principal
investigator) is Dr. Ivan Rosenberg of the Institute of Organic
Chemistry and Biochemistry in Prague, assisted by Drs. Tocik, Liboska and
Endova.
期刊论文(1)
专著(0)
科研奖励(0)
会议论文
Efficient synthesis of 2'-deoxynucleoside 3'-C-phosphonates: reactivity of geminal hydroxyphosphonate moiety.
2-脱氧核苷3-C-膦酸酯的有效合成:孪生羟基膦酸酯部分的反应性。
DOI:
10.1080/15257770008035038
发表时间:
2000
期刊:
Nucleosides, nucleotides & nucleic acids.
影响因子:
--
作者:
[Kralikova,S, Budyysinsky,M, Masojidkova,M, Rosenberg,I]
通讯作者:
Rosenberg,I
CORE--Technology and Regulatory Core Unit
-
批准号:6809180
-
项目类别:
-
资助金额:$23.4万
-
财政年份:2004
-
负责人:A ROBERT ROBERT NEURATH
-
依托单位:
Anti-HIV-1 Composite Cellulose Acetate Phthalate Film
-
批准号:6803829
-
项目类别:
-
资助金额:$123.24万
-
财政年份:2004
-
负责人:A ROBERT ROBERT NEURATH
-
依托单位:
Anti-HIV-1 Composite Cellulose Acetate Phthalate Film
-
批准号:6953768
-
项目类别:
-
资助金额:$128.33万
-
财政年份:2004
-
负责人:A ROBERT ROBERT NEURATH
-
依托单位:
Anti-HIV Microbicide: Cellulose Acetate Phthalate (CAP)
-
批准号:6797384
-
项目类别:
-
资助金额:$99.75万
-
财政年份:2001
-
负责人:A ROBERT ROBERT NEURATH
-
依托单位:
Anti-HIV Microbicide: Cellulose Acetate Phthalate (CAP)
-
批准号:6608543
-
项目类别:
-
资助金额:$111.48万
-
财政年份:2001
-
负责人:A ROBERT ROBERT NEURATH
-
依托单位:
Anti-HIV Microbicide: Cellulose Acetate Phthalate (CAP)
-
批准号:6443010
-
项目类别:
-
资助金额:$98.89万
-
财政年份:2001
-
负责人:A ROBERT ROBERT NEURATH
-
依托单位:
Anti-HIV Microbicide: Cellulose Acetate Phthalate (CAP)
-
批准号:6526238
-
项目类别:
-
资助金额:$109.6万
-
财政年份:2001
-
负责人:A ROBERT ROBERT NEURATH
-
依托单位:
HIV-1 PG120 V3 LOOP TARGETING--NOVEL POTENTIAL INHIBITOR
-
批准号:2460748
-
项目类别:
-
资助金额:$2.0万
-
财政年份:1996
-
负责人:A ROBERT ROBERT NEURATH
-
依托单位:
HIV-1 PG120 V3 LOOP TARGETING--NOVEL POTENTIAL INHIBITOR
-
批准号:2292288
-
项目类别:
-
资助金额:$2.0万
-
财政年份:1996
-
负责人:A ROBERT ROBERT NEURATH
-
依托单位:
SMALL INSTRUMENTATION GRANT
-
批准号:3523642
-
项目类别:
-
资助金额:$1.81万
-
财政年份:1991
-
负责人:A ROBERT ROBERT NEURATH
-
依托单位:
HIV-1 ENV PROTEINS--TARGETS FOR ANTIVIRAL CHEMOTHERAPY
-
批准号:2091161
-
项目类别:
-
资助金额:$26.08万
-
财政年份:1989
-
负责人:A ROBERT ROBERT NEURATH
-
依托单位:
HIV-1 ENV PROTEINS--TARGETS FOR ANTIVIRAL CHEMOTHERAPY
-
批准号:2091163
-
项目类别:
-
资助金额:$28.53万
-
财政年份:1989
-
负责人:A ROBERT ROBERT NEURATH
-
依托单位:
EPITOPE MAPPING OF HIV-1 ENHANCING ANTIBODIES
-
批准号:2064956
-
项目类别:
-
资助金额:$20.19万
-
财政年份:1989
-
负责人:A ROBERT ROBERT NEURATH
-
依托单位:
EPITOPE MAPPING OF HIV-1 ENHANCING ANTIBODIES
-
批准号:3144159
-
项目类别:
-
资助金额:$19.64万
-
财政年份:1989
-
负责人:A ROBERT ROBERT NEURATH
-
依托单位:
HIV-1 ENV PROTEINS--TARGETS FOR ANTIVIRAL CHEMOTHERAPY
-
批准号:3185495
-
项目类别:
-
资助金额:$26.38万
-
财政年份:1989
-
负责人:A ROBERT ROBERT NEURATH
-
依托单位:
EPITOPE MAPPING OF HIV-1 ENHANCING ANTIBODIES
-
批准号:3144156
-
项目类别:
-
资助金额:$15.54万
-
财政年份:1989
-
负责人:A ROBERT ROBERT NEURATH
-
依托单位:
EPITOPE MAPPING OF HIV-1 ENHANCING ANTIBODIES
-
批准号:3144157
-
项目类别:
-
资助金额:$17.43万
-
财政年份:1989
-
负责人:A ROBERT ROBERT NEURATH
-
依托单位:
SYNTHETIC HIV-1 ENV PROTEIN ANALOGS FOR FUTURE VACCINES
-
批准号:3185493
-
项目类别:
-
资助金额:$25.06万
-
财政年份:1989
-
负责人:A ROBERT ROBERT NEURATH
-
依托单位:
HIV-1 ENV PROTEINS--TARGETS FOR ANTIVIRAL CHEMOTHERAPY
-
批准号:2091162
-
项目类别:
-
资助金额:$27.32万
-
财政年份:1989
-
负责人:A ROBERT ROBERT NEURATH
-
依托单位:
EPITOPE MAPPING OF HIV-1 ENHANCING ANTIBODIES
-
批准号:3144158
-
项目类别:
-
资助金额:$18.59万
-
财政年份:1989
-
负责人:A ROBERT ROBERT NEURATH
-
依托单位:
海外基金