CORE--Technology and Regulatory Core Unit
CORE--Technology and Regulatory Core Unit
批准号:
6809180
负责人:
A ROBERT ROBERT NEURATH
金额:
$23.4万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2004
资助国家:
美国
项目状态:
已结题
起止时间:
2004-04-01 至 2009-03-31
关键词:
analytical methodantiinfective agentsbiomedical facilitycooperative studycyclodextrinsdrug design /synthesis /productiondrug interactionsdrug screening /evaluationhealth related legalinhibitor /antagonistmethod developmentmolecular filmphthalatesreverse transcriptase inhibitorstechnology /techniquetopical drug applicationvirus replication
中文摘要
该核心(“核心B”)将实现整个项目的两个目标:(1)提供商业化大规模生产CAP薄膜所需的知识;(2)建立邻苯二甲酸纤维素醋酸酯(CAP) /锌指抑制剂(ZnFI) /逆转录酶(RT)抑制剂UC781 /羟丙基- β -环糊精(hp - β - cd)联合杀菌剂的最佳参数。这项复杂的任务将得到学术界五个核心站点的支持[纽约血液中心(c);NIH/NCI (d)]和商业公司[粘合剂研究(a)];陶氏化学制药
英文摘要
This core ("Core B") will enable the two goals of the entire project: (1) provide knowledge needed for commercial mass production of CAP films and (2) establish optimal parameters for cellulose acetate phthalate (CAP) / zinc finger inhibitor (ZnFI) / reverse transcriptase (RT) inhibitor UC781 / hydroxypropyl-beta-cyclodextrin (HP-beta-CD ) combination microbicides. This complex task will be supported by five Core sites from academia [New York Blood Center (c); NIH/NCI (d)] and commercial companies [Adhesives Research (a); Dow Pharmaceutical
Sciences (b): Bioqual (e);]. The primary role of these company sites is goal 1 by providing scientific, technological, analytical and regulatory support, based on iterative studies, for Project IV (Clinical development of CAP microbicide films). Once goal 1 of the Program Project is accomplished in laboratory scale and animal experiments, goal I will also encompass combination microbicides. Core Bc, in collaboration with Core Ba, will provide Project by Jiang (in vitro efficacy of CAP film & microbicide combinations)and Project by Harouse (in vivo
safety and efficacy of CAP and combination films) with defined CAP films, microbicide combinations, and combination films to establish the safety, efficacy tn vitro and in animal models, and mucosal distribution of these products. Core Bc, in collaboration with Core Ba. Bb and Bd, will also provide analytical support. Core Bd will provide ZnFIs and analytical and regulatory support related to ZnFIs.
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Anti-HIV-1 Composite Cellulose Acetate Phthalate Film
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批准号:6803829
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项目类别:
-
资助金额:$123.24万
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财政年份:2004
-
负责人:A ROBERT ROBERT NEURATH
-
依托单位:
Anti-HIV-1 Composite Cellulose Acetate Phthalate Film
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批准号:6953768
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项目类别:
-
资助金额:$128.33万
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财政年份:2004
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负责人:A ROBERT ROBERT NEURATH
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依托单位:
Anti-HIV Microbicide: Cellulose Acetate Phthalate (CAP)
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批准号:6608543
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项目类别:
-
资助金额:$111.48万
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财政年份:2001
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负责人:A ROBERT ROBERT NEURATH
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依托单位:
Anti-HIV Microbicide: Cellulose Acetate Phthalate (CAP)
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批准号:6797384
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项目类别:
-
资助金额:$99.75万
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财政年份:2001
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负责人:A ROBERT ROBERT NEURATH
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依托单位:
Anti-HIV Microbicide: Cellulose Acetate Phthalate (CAP)
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批准号:6443010
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项目类别:
-
资助金额:$98.89万
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财政年份:2001
-
负责人:A ROBERT ROBERT NEURATH
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依托单位:
Anti-HIV Microbicide: Cellulose Acetate Phthalate (CAP)
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批准号:6526238
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项目类别:
-
资助金额:$109.6万
-
财政年份:2001
-
负责人:A ROBERT ROBERT NEURATH
-
依托单位:
HIV-1 PG120 V3 LOOP TARGETING--NOVEL POTENTIAL INHIBITOR
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批准号:2460748
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项目类别:
-
资助金额:$2.0万
-
财政年份:1996
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负责人:A ROBERT ROBERT NEURATH
-
依托单位:
HIV-1 PG120 V3 LOOP TARGETING--NOVEL POTENTIAL INHIBITOR
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批准号:2292288
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项目类别:
-
资助金额:$2.0万
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财政年份:1996
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负责人:A ROBERT ROBERT NEURATH
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依托单位:
HIV-1 PG120 V3 LOOP TARGETING--NOVEL POTENTIAL INHIBITOR
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批准号:2751045
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项目类别:
-
资助金额:$2.0万
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财政年份:1996
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负责人:A ROBERT ROBERT NEURATH
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依托单位:
SMALL INSTRUMENTATION GRANT
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批准号:3523642
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项目类别:
-
资助金额:$1.81万
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财政年份:1991
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负责人:A ROBERT ROBERT NEURATH
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依托单位:
HIV-1 ENV PROTEINS--TARGETS FOR ANTIVIRAL CHEMOTHERAPY
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批准号:2091161
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项目类别:
-
资助金额:$26.08万
-
财政年份:1989
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负责人:A ROBERT ROBERT NEURATH
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依托单位:
HIV-1 ENV PROTEINS--TARGETS FOR ANTIVIRAL CHEMOTHERAPY
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批准号:2091163
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项目类别:
-
资助金额:$28.53万
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财政年份:1989
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负责人:A ROBERT ROBERT NEURATH
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依托单位:
EPITOPE MAPPING OF HIV-1 ENHANCING ANTIBODIES
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批准号:2064956
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项目类别:
-
资助金额:$20.19万
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财政年份:1989
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负责人:A ROBERT ROBERT NEURATH
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依托单位:
EPITOPE MAPPING OF HIV-1 ENHANCING ANTIBODIES
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批准号:3144159
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项目类别:
-
资助金额:$19.64万
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财政年份:1989
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负责人:A ROBERT ROBERT NEURATH
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依托单位:
HIV-1 ENV PROTEINS--TARGETS FOR ANTIVIRAL CHEMOTHERAPY
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批准号:3185495
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项目类别:
-
资助金额:$26.38万
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财政年份:1989
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负责人:A ROBERT ROBERT NEURATH
-
依托单位:
EPITOPE MAPPING OF HIV-1 ENHANCING ANTIBODIES
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批准号:3144156
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项目类别:
-
资助金额:$15.54万
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财政年份:1989
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负责人:A ROBERT ROBERT NEURATH
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依托单位:
EPITOPE MAPPING OF HIV-1 ENHANCING ANTIBODIES
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批准号:3144157
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项目类别:
-
资助金额:$17.43万
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财政年份:1989
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负责人:A ROBERT ROBERT NEURATH
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依托单位:
HIV-1 ENV PROTEINS--TARGETS FOR ANTIVIRAL CHEMOTHERAPY
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批准号:2091162
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项目类别:
-
资助金额:$27.32万
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财政年份:1989
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负责人:A ROBERT ROBERT NEURATH
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依托单位:
SYNTHETIC HIV-1 ENV PROTEIN ANALOGS FOR FUTURE VACCINES
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批准号:3185493
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项目类别:
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资助金额:$25.06万
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财政年份:1989
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负责人:A ROBERT ROBERT NEURATH
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依托单位:
EPITOPE MAPPING OF HIV-1 ENHANCING ANTIBODIES
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批准号:3144158
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项目类别:
-
资助金额:$18.59万
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财政年份:1989
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负责人:A ROBERT ROBERT NEURATH
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依托单位:
海外基金