COLLABORATIVE LONGITUDINAL STUDY OF PERSONALITY DISORDER

人格障碍的合作纵向研究

• 批准号: 2668829
• 负责人: LESLIE C MOREY
• 金额: $ 1.99万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-03-01 至 2000-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2668829
• 关键词: avoidance behavior; behavioral /social science research tag; clinical research; comorbidity; cooperative study; diagnosis design /evaluation; functional ability; health care service evaluation; health care service utilization; human subject; human therapy evaluation; interview; longitudinal human study; major depression; mental disorder chemotherapy; mental disorder diagnosis; obsessive compulsive disorder; personality disorders; prognosis; psychometrics; questionnaires; schizoid personality; young adult human (21-34)

The overall aim of this study is to provide a comprehensive picture of the course and outcome of four specific personality disorders (PDs): schizotypal (STPD), borderline (BPD), avoidant (AVPD), and obsessive- compulsive (OCPD). Using a prospective longitudinal, repeated measures design we will develop the same basic knowledge about course and outcome for the PDs that has previously resulted from similar investigations of affective and anxiety disorders. The absence of comparable data for individuals diagnosed with PDs represents an important gap in knowledge. To accomplish our overall aim we propose three approaches: I. descriptive, II. predictive, and III. validating. The descriptive approach will provide the basic data on stability of psychopathology and social impairment that allows comparison between the PDs and to similar data from Axis I disorders. The predictive approach will yield basic clinical insights into the determinants of prognosis within and across PDs. The validating approach will examine the homogeneity of descriptive and longitudinal features for the PDs as defined by the DSM system and how this compares with alternative schemes. To accomplish these aims, this proposal requests funds to recruit, rigorously assess, and follow a total sample of 750 subjects, aged 18 to 45, i.e., 150 of each of the four PDs and 150 controls with major depressive disorder (NDD). The sample will be large enough and sufficiently diverse ethnically to attain results generalizable to most clinical settings and to examine the application of several dimensional approaches.

本研究的总体目标是提供一个全面的图景 四种特定人格障碍 (PD) 的病程和结果： 精神分裂型 (STPD)、边缘型 (BPD)、回避型 (AVPD) 和强迫型 - 强迫症（OCPD）。 使用前瞻性纵向、重复测量 设计我们将发展关于课程和结果的相同基本知识 对于先前由类似调查得出的 PD 情感和焦虑障碍。 缺乏可比数据 被诊断患有帕金森病的个体代表了一个重要的知识空白。 为了实现我们的总体目标，我们提出了三种方法：I.描述性， 二.预测性，以及 III.验证。 描述性方法将 提供精神病理学和社会稳定性的基本数据 允许在 PD 和类似数据之间进行比较的损伤 I 轴紊乱。 预测方法将产生基本的临床结果 深入了解 PD 内部和之间的预后决定因素。 这 验证方法将检查描述性和 DSM 系统定义的 PD 的纵向特征以及如何 这与替代方案进行了比较。 为了实现这些目标，本提案要求提供资金来招募、 严格评估并跟踪 750 名年龄在 18 岁至 45，即四个 PD 中的每一个 150 个，以及具有主要功能的 150 个控制 抑郁症（NDD）。 样本足够大并且 种族足够多样化以获得可推广到大多数人的结果 临床环境并检查多个维度的应用 接近。