COLLABORATIVE LONGITUDINAL STUDY OF PERSONALITY DISORDER

人格障碍的合作纵向研究

• 批准号: 6053957
• 负责人: LESLIE C MOREY
• 金额: $ 5.94万
• 依托单位: TEXAS A&M UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-03-01 至 2005-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6053957
• 关键词: avoidance behavior; behavioral /social science research tag; borderline personality disorder; clinical research; comorbidity; cooperative study; diagnosis design /evaluation; disease /disorder classification; disease /disorder model; disease /disorder proneness /risk; functional ability; health care service utilization; human subject; interview; longitudinal human study; model design /development; obsessive compulsive disorder; outcomes research; pathologic process; psychometrics; questionnaires; schizoid personality; young adult human (21-34)

Description: (Adapted from Applicant's Abstract) The overall aim of this study is to provide a comprehensive picture of the course and outcome of four specific personality disorders (PDs): schizotypal (STPD), borderline (BPI), avoidant (AVPD), and obsessive-compulsive (OCPD). The present proposal continues a multi-site collaborative effort to follow a carefully diagnosed sample of 668 subjects having either these representative PDs or major depressive disorder (MDD) (controls) for the period from 2 to a minimum of 6 years after recruitment. Using a prospective, longitudinal, repeated measures design, we will develop the same basic knowledge about course and outcome for the PDs that has previously resulted from similar investigations of affective and anxiety disorders, thus addressing an important gap in our knowledge. The extended period of follow-up is essential to discern clinically meaningful descriptions of course and outcome and their determinants. The sample is large enough and sufficiently diverse demographically to attain a unique array of results generalized to most clinical settings. To accomplish our overall aim, we propose three approaches I. Descriptive, II. Predictive, and III. Validating. The descriptive approach will provide data on diagnostic stability of PDs, on presence and course of comorbid Axis I disorders, on persistence of functional impairment, and on utilization of health care resources that allow comparison between the PDs and similar data on Axis I disorders. The predictive approach will identify clinically meaningful determinants of prognosis within and across PDs. The validating approach will examine the homogeneity of descriptive and longitudinal features for the PDs, as defined by the DSM system, and how this compares with alternative schemes.

描述：（改编自申请人摘要）本研究的总体目标 是提供一个全面的过程和结果的四个 特殊人格障碍（PD）：典型型（STPD），边缘型（BPI）， 回避型（AVPD）和强迫型（OCPD）。现时的建议 继续进行多站点协作， 668例患有这些代表性PD或主要PD的受试者样本 抑郁症（MDD）（对照组），持续时间为2至至少6年 招募后的几年采用前瞻性、纵向、重复测量 设计，我们将开发有关过程和结果相同的基本知识， 以前从情感的类似调查中得出的PD 和焦虑症，从而填补了我们知识上的一个重要空白。的 延长随访期对于识别临床意义 描述过程和结果及其决定因素。样本量大 在人口统计学上有足够的多样性， 结果推广到大多数临床环境。 为了实现我们的总体目标，我们提出了三种方法。描述性的，II. 预测，三。确认中描述性方法将提供以下数据： PD的诊断稳定性，关于合并症轴I的存在和病程 功能障碍的持续性，以及使用 卫生保健资源，允许比较PD和类似数据， I轴紊乱。预测方法将识别出具有临床意义的 PD内和PD间预后的决定因素。验证方法将 检查PD的描述性和纵向特征的同质性， 如DSM系统所定义的，以及与其他方案的比较。