COLLABORATIVE LONGITUDINAL STUDY OF PERSONALITY DISORDER

人格障碍的合作纵向研究

• 批准号: 2883373
• 负责人: LESLIE C MOREY
• 金额: $ 5.23万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-03-01 至 2000-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2883373
• 关键词: avoidance behavior; behavioral /social science research tag; clinical research; comorbidity; cooperative study; diagnosis design /evaluation; functional ability; health care service evaluation; health care service utilization; human subject; human therapy evaluation; interview; longitudinal human study; major depression; mental disorder chemotherapy; mental disorder diagnosis; obsessive compulsive disorder; personality disorders; prognosis; psychometrics; questionnaires; schizoid personality; young adult human (21-34)

The overall aim of this study is to provide a comprehensive picture of the course and outcome of four specific personality disorders (PDs): schizotypal (STPD), borderline (BPD), avoidant (AVPD), and obsessive- compulsive (OCPD). Using a prospective longitudinal, repeated measures design we will develop the same basic knowledge about course and outcome for the PDs that has previously resulted from similar investigations of affective and anxiety disorders. The absence of comparable data for individuals diagnosed with PDs represents an important gap in knowledge. To accomplish our overall aim we propose three approaches: I. descriptive, II. predictive, and III. validating. The descriptive approach will provide the basic data on stability of psychopathology and social impairment that allows comparison between the PDs and to similar data from Axis I disorders. The predictive approach will yield basic clinical insights into the determinants of prognosis within and across PDs. The validating approach will examine the homogeneity of descriptive and longitudinal features for the PDs as defined by the DSM system and how this compares with alternative schemes. To accomplish these aims, this proposal requests funds to recruit, rigorously assess, and follow a total sample of 750 subjects, aged 18 to 45, i.e., 150 of each of the four PDs and 150 controls with major depressive disorder (NDD). The sample will be large enough and sufficiently diverse ethnically to attain results generalizable to most clinical settings and to examine the application of several dimensional approaches.

这项研究的总体目的是提供一个全面的画面

项目成果

The impact of comorbid dysthymic disorder on outcome in personality disorders.

共病心境恶劣障碍对人格障碍结果的影响。

• DOI: 10.1016/j.comppsych.2009.11.002
• 发表时间: 2010
• 期刊: Comprehensive psychiatry
• 影响因子: 7.3
• 作者: Hellerstein,DavidJ;Skodol,AndrewE;Petkova,Eva;Xie,Hui;Markowitz,JohnC;Yen,Shirley;Gunderson,John;Grilo,Carlos;Daversa,MariaT;McGlashan,ThomasH
• 通讯作者: McGlashan,ThomasH