REHABILITATION, BRAIN LESIONS, AND MOVEMENT IN INFANTS

婴儿的康复、脑损伤和运动

• 批准号: 2445810
• 负责人: EDWARD TRONICK
• 金额: $ 27.79万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-01 至 1999-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2445810
• 关键词: body movement; brain disorder diagnosis; brain disorders; brain mapping; diagnosis design /evaluation; disease /disorder classification; gait; human subject; limb movement; longitudinal human study; low birth weight infant human; magnetic resonance imaging; maternal behavior; motor cortex; neuropsychological tests; performance; prognosis; psychomotor disorders; psychomotor function; questionnaires; rehabilitation

The primary goals of this project are to evaluate the parameters of movement as measured by kinematic techniques of Very Low Birth weight (VLBW) infants with and without Neonatal White Matter Disorder (NWMD) and healthy full term (FT) infants without NWMD as detected by ultrasound (US) or magnetic resonance (MRI) over the first 18 months of life corrected age (CA); to evaluate the predictive relations of the parameters of movement to later dysfunction and to compare the prognostic effectiveness of imaging and kinematic techniques; as well as, to evaluate the immature brain's ability to recover from NWMD. At the base, we believe we will begin to describe the early natural history of NWMD and the developing brain's ability to compensate for structural damage. The proposed project is a longitudinal prospective study of 40 VLBW infants with documented NWMD at birth and 40 VLBW infants free of such lesions and 20 FT infants free of NWMD. To characterize the location and size of the lesions and their changes over time, including their appearance beyond the neonatal period, high resolution cranial US will be repeated during the neonatal period and at 3 months CA and MRI will be administered at 6 months CA. The spontaneous and elicited movement patterns of the lower and upper limbs of the three groups Of infants will be evaluated at 2, 5, 9 and 18 months CA using kinematic techniques. The clinical and functional status of the infants will be evaluated with the Neonatal Behavioral Assessment Scale (NBAS) twice during the neonatal period; with the Alberta Infant Motor Screen (MMS) at 5 and 9 months CA; with a standard neurological examination at 6 and 18 months carried out by a pediatric neurologist; with the Peabody Developmental Motor Scales- and with the Pediatric Evaluation of Disability Inventory (PEDI) at 18 months CA. Additionally, to make an initial evaluation of the role of experience, three questionnaires that measure the quality of the caretaking environment will be administered. We expect that infants who have NWMD, particularly near the fronto- parietal junction with or without ventriculomegaly or hemorrhage, will manifest early atypical organization of movement which can be detected by kinematic techniques.

该项目的主要目标是评估 运动技术测量极低出生体重儿的运动 患有和不患有新生儿白色物质障碍（NWMD）的极低出生体重（VLBW）婴儿，以及 通过超声（US）检测无NWMD的健康足月（FT）婴儿 或磁共振（MRI）在生命校正年龄的前18个月 (CA)评价运动参数的预测关系 并比较以下因素的预后有效性： 成像和运动学技术;以及，评估未成熟的 大脑从NWMD中恢复的能力。在基地，我们相信 开始描述大规模杀伤性武器的早期自然历史， 大脑对结构性损伤的补偿能力 建议的项目是一项纵向前瞻性研究， 出生时有记录的NWMD婴儿和40名无此类记录的VLBW婴儿 病变和20名FT婴儿无NWMD。描述位置特征并 病变的大小及其随时间的变化，包括其 出现超过新生儿期，高分辨率颅超声将 在新生儿期和3个月时重复CA和MRI， 在CA 6个月时给药。自发的和诱发的运动 三组婴儿的下肢和上肢的模式将 使用运动学技术在CA 2、5、9和18个月时进行评估。的 婴儿的临床和功能状态将通过 新生儿行为评估量表（NBAS）在新生儿期间进行两次 在出生后5个月和9个月时进行阿尔伯塔婴儿运动筛查; 在6个月和18个月时进行标准神经系统检查， 一位儿科神经学家;用皮博迪发育运动量表-和 在18个月时使用儿科残疾评估量表（PEDI） 约此外，为了对经验的作用进行初步评价， 三份调查问卷， 环境将得到管理。 我们预计，患有大规模毁灭性武器的婴儿，特别是靠近额部的婴儿， 顶叶交界处伴或不伴脑室扩大或出血， 表现出早期的非典型运动组织，可以通过以下方式检测到： 运动学技术