STANDARDIZATION OF THE NRN: NEUROBEHAVIORAL SCALE

对于正常或高危婴儿在围产期的神经行为表现，尚无全面、标准化、规范化的评估。该项目的具体目的是利用独特的全面心理测量学量表--新生儿重症监护研究网络神经行为量表(NNNS)，为胎龄(GA)组和适当时性别和/或种族/族裔组制定围产期新生儿神经行为表现的标准化标准。NNNS的标准化将是新生儿、儿科、儿科神经病学和儿童发展研究的重大方法学进步。它将为评估神经行为状况与医疗和社会状况变量之间的关系以及评估医疗和发展干预措施(包括NICU生态的变化和早期干预)对围产期和老年神经行为状况的影响提供标准。此外，标准化工具将有助于比较研究和开发大型数据库。标准化规范将对临床护理产生重大影响，因为规范将识别功能异常或可疑的新生儿，并允许与正常相比对个别婴儿进行评估。我们建议对720名婴儿样本进行前瞻性纵向研究，按(1)GA：1]28-33周；2]34-37周；3)38-42周；(2)3个种族/民族(黑人、西班牙裔、白人)和(3)性别分层。在我们排除标准的范围内，婴儿的医疗和社会地位将自由变化。每个GA组的婴儿将接受三次NNNS检查：1)当医学稳定+3天或出生+1天时，2]足月(即对于足月组，这与出生+1天相同)，以及3]在44周GA时。将使用趋同措施仔细定义孕周。

There is no comprehensive standardized, normed assessment of neurobehavioral performance of normal Or high risk infants during the perinatal period. The specific aim of this project is to develop standardized norms for newborn neurobehavioral performance for gestational age (GA) groups and where appropriate, gender and/or race/ethnicity groups during the perinatal period using a uniquely comprehensive psychometrically sound scale, the Neonatal Intensive Care Research Network Neurobehavioral Scale (NNNS). Standardization of the NNNS will be a significant methodological advance for research in neonatology, pediatrics, pediatric neurology, and child development. It will provide norms to evaluate relations between neurobehavioral status and medical and social status variables, and to evaluate the effects of medical and developmental interventions (including changes in NICU ecology and early intervention) on neurobehavioral status during the perinatal period and at older ages. Furthermore, a standardized instrument will facilitate comparison of studies and the development of large data bases. Standardized norms will have a significant impact on clinical care because norms will identify neonates who are functionally abnormal or suspect and permit the evaluation of individual infants in comparison to the norms. We propose to carry out a prospective longitudinal study on a sample of 720 infants stratified by (1) GA: 1] 28-33 weeks; 2] 34-37 weeks; 3] 38-42 weeks; (2) 3 racial/ethnic groups (Black, Hispanic, White); and (3) gender. Within the boundaries of our exclusion criteria, the medical and social status of the infants will be free to vary. Infants in each GA group will be examined with the NNNS three times: 1] when medically stable +3 days or at Birth + 1 day, 2] Term (i.e., for the term group this is the same as Birth +1 day), and 3] at 44 weeks GA. Gestational age will be carefully defined using the converging measures.