MECHANISMS OF VASCULAR INJURY AFTER SPINAL CORD TRAUMA

脊髓创伤后血管损伤的机制

• 批准号: 2460556
• 负责人: EDWARD L. HOGAN
• 金额: $ 17.22万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-08-01 至 1999-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2460556
• 关键词: blood vessels; cellular pathology; cytotoxicity; eicosanoid metabolism; inflammation; kininogens; kinins; laboratory rat; neuroprotectants; nonhuman therapy evaluation; spinal cord injury; trauma

Early pharmacological intervention in acute spinal cord injury (SCI) is based on the premise that secondary injury following the initial insult contributes to ultimate spinal cord damage and neurologic deficit. This contention is strengthened by the recent observation of the Second National Acute Spinal Cord Injury Studies (NASCIS II) showing that high dose methylprednisolone given within 8 hours of injury improved neurologic recovery in patients with acute SCI. Progressive vascular injury after SCI contributes to secondary injury. Vascular injury is a prominent feature in acute inflammation. All the cardinal features of acute inflammation including deposition of acute inflammatory cells, accumulation of inflammatory mediators, endothelial damage leading to increased vascular permeability and edema formation have been noted in the injured cord. We will continue to explore the vascular mechanism of secondary injury focusing on post-traumatic inflammatory reaction in the pathogenesis of progressive vascular injury. The main theme of this proposal will be on the kininogen-kinin system and eicosanoid profile. The roles of cellular and humoral factors of inflammation relevant to kinin-eicosanoid cascade will be studied in depth to explore cellular and molecular mechanism of progressive vascular injury in the context of a post-traumatic inflammatory reaction. New therapeutic regimens will also be designed based on these studies.

急性脊髓损伤（SCI）的早期药物干预

项目成果

Characterization of novel myelin components 3-O-acetyl-sphingosine galactosylceramides by electrospray ionization Q-TOF MS and MS/CID-MS of Li+ adducts.

通过 Li 加合物的电喷雾电离 Q-TOF MS 和 MS/CID-MS 表征新型髓磷脂成分 3-O-乙酰基-鞘氨醇半乳糖神经酰胺。

• DOI: 10.1002/jms.1190
• 发表时间: 2007
• 期刊: Journal of mass spectrometry : JMS
• 作者: Bennion,Beau;Dasgupta,Somsankar;Hogan,EdwardL;Levery,StevenB
• 通讯作者: Levery,StevenB

Activation of JNK/SAPK in primary glial cultures: II. Differential activation of kinase isoforms corresponds to their differential expression.

原代胶质细胞培养中 JNK/SAPK 的激活：II。

• DOI: 10.1023/a:1022489127107
• 发表时间: 1998
• 期刊: Neurochemical research
• 影响因子: 4.4
• 作者: Zhang,P;Hogan,EL;Bhat,NR
• 通讯作者: Bhat,NR

Immunohistochemical localization of kininogen in rat spinal cord and brain.

大鼠脊髓和大脑中激肽原的免疫组织化学定位。

• DOI: 10.1006/exnr.1999.7165
• 发表时间: 1999
• 期刊: Experimental neurology.
• 作者: Li,Z;Tyor,WR;Xu,J;Chao,J;Hogan,EL
• 通讯作者: Hogan,EL