STANDARDIZATION OF A PC-BASED TEST OF IMPAIRMENT

第一阶段开发并测试了一种新的基于软件的分散注意力 使用彩色、无语言图形的认知表现测试 显示屏 测试运行在任何基于DOS的PC上，无需外部硬件 或对照。 该测试对酒精引起的损害更敏感 比以前的基于硬件的测试（平均呼吸酒精水平为0.045 0.079%）。 性能的主要优势- 它可以在任何软件平台上运行，无需外部 设备，不偏向于字母数字字符，可以自 管理，并设计为低成本（约400美元）。 第二阶段项目完成测试（性能在线） 通过一系列的分析和实验室研究， 该测试在检测酒精使用，药物使用， 药物使用，睡眠不足和疲劳。 我们的目标是开发 检测和分析方法均可接受， 现场研究和应用。 4项临床研究 检查变量以确认测试有效性：耐受性发展， 酒精，认知障碍，CNS镇静剂（阿普唑仑）和CNS 兴奋剂（苯丙胺），以及睡眠不足和疲劳的影响。 该项目还为测试用户开发分析程序，包括 可靠性和信号检测ROLC分析。 在线互动式 将完善与科学和企业订户的程序 这使得能够制定不断更新的基线规范， 监测尺寸、年龄、性别、职业、视力矫正，以及 身高体重比 将在一个阶段中提出工地评估 三是应用。

Phase I developed and tested a new software-based divided attention test of cognitive performance that used color, language-free graphic displays. The test ran on any DOS based-PC without external hardware or controls. The test was more sensitive to alcohol-induced impairment than previous hardware-based tests (mean breath alcohol levels of 0.045 percent and 0.079 percent). The main advantages of performance On- Line are that it can run on any soft-ware platform without external device, is not biased to alpha-numeric characters, can be self- administered, and is designed to be low cost (approximately $400). The Phase II project standardizes the test (Performance On-Line) through a series of analytical and laboratory studies which document the test's reliability and validity in detecting alcohol use, drug use, pharmaceutical use, and sleep loss and fatigue. The goal is to develop the test and analytical procedures to that both are acceptable for worksite research and applications. Four clinical research studies examine variables to confirm test validity: tolerance development to alcohol, cognitive impairment to a CNS sedative (alprazolam) and a CNS stimulant (dextroamphetamine), and the effects of sleep loss and fatigue. The project also develops analysis procedures for test users, including reliability and signal detection ROLC analyses. On-line interactive procedures with scientific and corporate subscribers will be refined which enable the development of continuously updated baseline norms on monitor size, age, gender, occupation, vision corrections, and height/weight ratio. A worksite evaluation will be proposed in a Phase III application.